Document
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Journal of Hazardous Materials
publication venue for: Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism
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Universidad Autónoma de San Luis Potosí, UASLP: C10-FRC-07-03.04
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funding vehicle for: Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism

Consejo Nacional de Ciencia y Tecnología, CONACYT: 28253-U, CB-2008-01-103532
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funding vehicle for: Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism

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RDF description of Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism - http://orbis.uaslp.mx/vivo/individual/scopus3250
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date: 2026-08-25T07:03:45
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Article
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Information Content Entity
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Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism
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abstract: The advanced oxidation of paracetamol (PAM) promoted by TiO2/UV system in aqueous medium was investigated. Monitoring this reaction by HPLC and TOC, it was demonstrated that while oxidation of paracetamol is quite efficient under these conditions, its mineralization is not complete. HPLC indicated the formation of hydroquinone, benzoquinone, p-aminophenol and p-nitrophenol in the reaction mixtures. Further evidence of p-nitrophenol formation was obtained following the reaction by UV-vis spectroscopy. Continuous monitoring by IR spectroscopy demonstrated the breaking of the aromatic amide present in PAM and subsequent formation of several aromatic intermediate compounds such as p-aminophenol and p-nitrophenol. These aromatic compounds were eventually converted into trans-unsaturated carboxylic acids. Based on these experimental results, an alternative deacylation mechanism for the photocatalytic oxidation of paracetamol is proposed. Our studies also demonstrated IR spectroscopy to be a useful technique to investigate oxidative mechanisms of pharmaceutical compounds. © 2012 Elsevier B.V.
chemicalscas: 4 aminophenol, 123-30-8; 4 nitrophenol, 100-02-7; hydroquinone, 123-31-9; paracetamol, 103-90-2; titanium dioxide, 1317-70-0, 1317-80-2, 13463-67-7, 51745-87-0; Acetaminophen, 103-90-2; Carbon, 7440-44-0; Carboxylic Acids; Titanium, 7440-32-6; titanium dioxide, 15FIX9V2JP
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has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 28253-U, CB-2008-01-103532
type: Article
estado: published
has funding vehicle: Universidad Autónoma de San Luis Potosí, UASLP: C10-FRC-07-03.04
has publication venue: Journal of Hazardous Materials
date time value: article date 3251
most specific type: Article
related by: authorship_18877
related by: authorship_18880
doi: 10.1016/j.jhazmat.2012.10.010
type: Information Content Entity
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freetext keyword: Paracetamol; Photocatalytic degradation; Reaction mechanism Advanced oxidation; Aqueous medium; Aromatic amides; Benzoquinones; Continuous monitoring; Deacylation mechanism; Intermediate compound; Oxidative mechanism; p-Aminophenol; p-Nitrophenol; Paracetamol; Pharmaceutical compounds; Photo catalytic degradation; Photocatalytic oxidations; Reaction mechanism; Reaction mixture; TiO; UV-vis spectroscopy; Amides; Carboxylic acids; Oxidation; Phenols; Photodegradation; Titanium dioxide; Ultraviolet visible spectroscopy; Reaction intermediates; 4 aminophenol; 4 nitrophenol; aromatic amide; benzoquinone; carboxylic acid derivative; hydroquinone; paracetamol; titanium dioxide; carboxylic acid; catalysis; drug; experimental study; mineralization; phenol; photodegradation; photooxidation; titanium; ultraviolet radiation; article; biotransformation; deacetylation; degradation; high performance liquid chromatography; infrared spectroscopy; oxidation; photocatalysis; reaction analysis; total organic carbon; ultraviolet spectroscopy; Acetaminophen; Carbon; Carboxylic Acids; Catalysis; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Oxidation-Reduction; Photochemistry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Titanium; Ultraviolet Rays
pmid: 23123003
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most specific type: Document
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related by: authorship_18878
crisid: 3251
page start: 130
origen: scopus
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related by: authorship_18881
e iscopus: 2-s2.0-84869886614
page end: 138
volume: 243