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Universidad Autónoma de San Luis Potosí, UASLP: C10-FRC-07-03.04
Consejo Nacional de Ciencia y Tecnología, CONACYT: 28253-U, CB-2008-01-103532
Generically Dependent Continuant
RDF description of Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism - http://orbis.uaslp.mx/vivo/individual/scopus3250
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The advanced oxidation of paracetamol (PAM) promoted by TiO2/UV system in aqueous medium was investigated. Monitoring this reaction by HPLC and TOC, it was demonstrated that while oxidation of paracetamol is quite efficient under these conditions, its mineralization is not complete. HPLC indicated the formation of hydroquinone, benzoquinone, p-aminophenol and p-nitrophenol in the reaction mixtures. Further evidence of p-nitrophenol formation was obtained following the reaction by UV-vis spectroscopy. Continuous monitoring by IR spectroscopy demonstrated the breaking of the aromatic amide present in PAM and subsequent formation of several aromatic intermediate compounds such as p-aminophenol and p-nitrophenol. These aromatic compounds were eventually converted into trans-unsaturated carboxylic acids. Based on these experimental results, an alternative deacylation mechanism for the photocatalytic oxidation of paracetamol is proposed. Our studies also demonstrated IR spectroscopy to be a useful technique to investigate oxidative mechanisms of pharmaceutical compounds. © 2012 Elsevier B.V.
4 aminophenol, 123-30-8; 4 nitrophenol, 100-02-7; hydroquinone, 123-31-9; paracetamol, 103-90-2; titanium dioxide, 1317-70-0, 1317-80-2, 13463-67-7, 51745-87-0; Acetaminophen, 103-90-2; Carbon, 7440-44-0; Carboxylic Acids; Titanium, 7440-32-6; titanium dioxide, 15FIX9V2JP
Photocatalytic degradation of paracetamol: Intermediates and total reaction mechanism
Paracetamol; Photocatalytic degradation; Reaction mechanism Advanced oxidation; Aqueous medium; Aromatic amides; Benzoquinones; Continuous monitoring; Deacylation mechanism; Intermediate compound; Oxidative mechanism; p-Aminophenol; p-Nitrophenol; Paracetamol; Pharmaceutical compounds; Photo catalytic degradation; Photocatalytic oxidations; Reaction mechanism; Reaction mixture; TiO; UV-vis spectroscopy; Amides; Carboxylic acids; Oxidation; Phenols; Photodegradation; Titanium dioxide; Ultraviolet visible spectroscopy; Reaction intermediates; 4 aminophenol; 4 nitrophenol; aromatic amide; benzoquinone; carboxylic acid derivative; hydroquinone; paracetamol; titanium dioxide; carboxylic acid; catalysis; drug; experimental study; mineralization; phenol; photodegradation; photooxidation; titanium; ultraviolet radiation; article; biotransformation; deacetylation; degradation; high performance liquid chromatography; infrared spectroscopy; oxidation; photocatalysis; reaction analysis; total organic carbon; ultraviolet spectroscopy; Acetaminophen; Carbon; Carboxylic Acids; Catalysis; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Oxidation-Reduction; Photochemistry; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Titanium; Ultraviolet Rays