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Generically Dependent Continuant
RDF description of Role of IL-6 in the etiology of hyperexcitable neuropsychiatric conditions: Experimental evidence and therapeutic implications - http://orbis.uaslp.mx/vivo/individual/scopus3187
Article
mitogen activated protein kinase, 142243-02-5; somatomedin C, 67763-96-6; Interleukin-6
Role of IL-6 in the etiology of hyperexcitable neuropsychiatric conditions: Experimental evidence and therapeutic implications
Many neuropsychiatric conditions are primed or triggered by different types of stressors. The mechanisms through which stress induces neuropsychiatric disease are complex and incompletely understood. A 'double hit hypothesis of neuropsychiatric disease postulates that stress induces maladaptive behavior in two phases separated by a dormant period. Recent research shows that the pleiotropic cytokine IL-6 is released centrally and peripherally following physical and psychological stress. In this article, we analyze evidence from clinics and animal models suggesting that stress-induced elevation in the levels of IL-6 may play a key role in the etiology of a heterogeneous family of hyperexcitable central conditions including epilepsy, schizophrenic psychoses, anxiety and disorders of the autistic spectrum. The cellular mechanism leading to hyperexcitable conditions might be a decrease in inhibitory/excitatory synaptic balance in either or both temporal phases of the conditions. Following these observations, we discuss how they may have important implications for optimal prophylactic and therapeutic pharmacological treatment. © 2012 Future Science Ltd.
interleukin 6; mitogen activated protein kinase; somatomedin C; STAT protein; anxiety disorder; article; autism; central nervous system; cytokine release; epilepsy; GABAergic system; priority journal; schizophrenia; schizophreniform disorder; signal transduction; stress; synapse; Animals; Anxiety Disorders; Brain; Child; Child Development Disorders, Pervasive; Drug Discovery; Epilepsy; Humans; Interleukin-6; Molecular Targeted Therapy; Schizophrenia; Stress, Physiological; Stress, Psychological
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