Document
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Immunogenetics
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publication venue for: Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections
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RDF description of Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections - http://orbis.uaslp.mx/vivo/individual/scopus3161
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date: 2026-08-24T21:53:11
publisher: vivo
type: Document

Article
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Information Content Entity
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Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections
abstract: Introduction of a novel influenza virus into the human population leads to the occurrence of pandemic events, such as the one caused by pandemic influenza A (H1N1) 2009 virus. The severity of infections caused by this virus in young adults was greater than that observed in patients with seasonal influenza. Fatal cases have been associated with an abnormal innate, proinflammatory immune response. A critical role for natural killer cells during the initial responses to influenza infections has been suggested. In this study, we assessed the association of killercell immunoglobulin-like receptors (KIRs) with disease severity by comparing KIR gene content in patients with mild and severe pandemic influenza virus infections to a control group. We found that activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes, encoded in group B haplotypes containing the cB01, cB03 and tB01 motifs, are associated with severe pandemic influenza A (H1N1) 2009 infections. Better understanding of how genetic variability contributes to influenza virus pathogenesis may help to the development of immune intervention strategies aiming at controlling the severity of disease. © Springer-Verlag 2012.
most specific type: Document
related by: authorship_18402
has publication venue: Immunogenetics
related by: authorship_18404
crisid: 3162
estado: published
freetext keyword: H1N1; Immunogenetics; Influenza; KIR; NK cells; Pandemic influenza killer cell immunoglobulin like receptor; killer cell immunoglobulin like receptor 2DL5; killer cell immunoglobulin like receptor 2DS5; killer cell immunoglobulin like receptor 3DS1; unclassified drug; 2009 H1N1 influenza; adolescent; adult; aged; arthralgia; article; blood sampling; child; clinical article; controlled study; coughing; disease association; disease severity; dyspnea; female; fever; genetic variability; genotype; haplotype; headache; human; Influenza virus A H1N1; lower respiratory tract infection; male; myalgia; pandemic influenza; pathogenesis; pharynx; preschool child; priority journal; protein motif; reverse transcription polymerase chain reaction; rhinorrhea; school child; upper respiratory tract infection; virus identification; Adolescent; Adult; Aged; Amino Acid Motifs; Child; Child, Preschool; Female; Gene Frequency; Genotype; Haplotypes; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Male; Mexico; Middle Aged; Pandemics; Protein Isoforms; Receptors, KIR; Receptors, KIR2DL5; Receptors, KIR3DS1; Severity of Illness Index; Young Adult; Orthomyxoviridae
related by: authorship_18398
origen: scopus
type: Thing
date time value: article date 3162
type: Entity
page end: 662
issue: 9
related by: authorship_18399
pmid: 22652695
doi: 10.1007/s00251-012-0623-3
page start: 653
type: Document
related by: authorship_18403
related by: authorship_18401
volume: 64
chemicalscas: KIR2DS5 protein, human; Protein Isoforms; Receptors, KIR; Receptors, KIR2DL5; Receptors, KIR3DS1
e iscopus: 2-s2.0-84866739946
related by: authorship_18400
type: Continuant
type: Information Content Entity
most specific type: Article
type: Article
type: Generically Dependent Continuant