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date: 2026-08-25T22:11:53
publisher: vivo
type: Document
label: RDF description of NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the tractus solitarius, of type-II diabetic patients - http://orbis.uaslp.mx/vivo/individual/scopus3133

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NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the tractus solitarius, of type-II diabetic patients
type: Entity
related by: authorship_18243
freetext keyword: alpha intermedin; nerve growth factor; neuropeptide Y; tyrosine 3 monooxygenase; aged; arcuate nucleus; article; autopsy; brain nerve cell; brain stem; clinical article; controlled study; down regulation; female; human; human tissue; male; non insulin dependent diabetes mellitus; nonhuman; protein localization; rodent; solitary tract nucleus; Adult; Aged; alpha-MSH; Arcuate Nucleus; Autopsy; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gene Expression Regulation; Humans; Immunohistochemistry; Male; Middle Aged; Nerve Growth Factors; Neurons; Neuropeptide Y; Solitary Nucleus; Animalia; Rodentia
doi: 10.1371/journal.pone.0040070
related by: authorship_18240
most specific type: Document
volume: 7
type: Thing
related by: authorship_18246
abstract: Ample animal studies demonstrate that neuropeptides NPY and α-MSH expressed in Arcuate Nucleus and Nucleus of the Tractus Solitarius, modulate glucose homeostasis and food intake. In contrast is the absence of data validating these observations for human disease. Here we compare the post mortem immunoreactivity of the metabolic neuropeptides NPY, αMSH and VGF in the infundibular nucleus, and brainstem of 11 type-2 diabetic and 11 non-diabetic individuals. α-MSH, NPY and tyrosine hydroxylase in human brain are localized in the same areas as in rodent brain. The similar distribution of NPY, α-MSH and VGF indicated that these neurons in the human brain may share similar functionality as in the rodent brain. The number of NPY and VGF immuno positive cells was increased in the infundibular nucleus of diabetic subjects in comparison to non-diabetic controls. In contrast, NPY and VGF were down regulated in the Nucleus of the Tractus Solitarius of diabetic patients. These results suggest an activation of NPY producing neurons in the arcuate nucleus, which, according to animal experimental studies, is related to a catabolic state and might be the basis for increased hepatic glucose production in type-2 diabetes. © 2012 Saderi et al.
date time value: article date 3134
crisid: 3134
type: Document
related by: authorship_18241
most specific type: Article
related by: authorship_18244
type: Information Content Entity
related by: authorship_18247
chemicalscas: nerve growth factor, 9061-61-4; neuropeptide Y, 82785-45-3, 83589-17-7; tyrosine 3 monooxygenase, 9036-22-0; Nerve Growth Factors; Neuropeptide Y; VGF protein, human; alpha-MSH, 581-05-5
e iscopus: 2-s2.0-84863826807
related by: authorship_18242
has publication venue: PLoS ONE
related by: authorship_18239
artnum: e40070
type: Article
type: Continuant
origen: scopus
related by: authorship_18245
pmid: 22808091
type: Generically Dependent Continuant
estado: published
issue: 7
accesstype: All Open Access, Gold, Green

PLoS ONE
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publication venue for: NPY and VGF immunoreactivity increased in the arcuate nucleus, but decreased in the nucleus of the tractus solitarius, of type-II diabetic patients
type: Thing
type: Journal
type: Entity