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Toxicology
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publication venue for: Arsenic-cadmium interaction in rats: toxic effects in the heart and tissue metal shifts
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RDF description of Arsenic-cadmium interaction in rats: toxic effects in the heart and tissue metal shifts - http://orbis.uaslp.mx/vivo/individual/scopus274
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date: 2026-08-24T21:51:11
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type: Document

Arsenic-cadmium interaction in rats: toxic effects in the heart and tissue metal shifts
pmid: 2031255
page start: 227
e iscopus: 2-s2.0-0025853943
abstract: Previously, we had shown that arsenic interacts with cadmium in rats; our results showed that the toxicity of a mixture of arsenic cadmium cannot be predicted by the toxic mechanisms of the individual components. In this paper, we present further evidence about the interaction of arsenic and cadmium in rats. The results were: arsenic modified the 24 h-LD50 value of cadmium more clearly than cadmium did with the one of arsenic; based on the LD50 values, the mixtures we studied were more toxic than either metal alone. With single doses (As 10 mg/kg, Cd 2.6 mg/kg, and As 10 mg/kg Cd 2.6 mg/kg) the mixture As Cd was more toxic than each metal. At these doses, cadmium significantly induces the levels of glutathione, metallothionein, and lipid peroxidation in heart tissue, as compared to a saline group of rats. Arsenic incremented glutathione and lipid peroxidation at higher values than those obtained with cadmium. The mixture of As Cd behaved as arsenic in the induction of lipid peroxidation and glutathione and like cadmium in metallothionein induction. Finally, rats treated with As Cd had less Cd in liver than animals treated only with cadmium, and more As in heart tissue than rats treated only with arsenic. Our results give further evidence about the arsenic-cadmium interaction in rats, demonstrate the utility of employing different biomarkers in the study of chemical mixtures and indicate that heart tissue is affected not only by the mixture of As Cd, but also by either metal alone. © 1991.
type: Document
related by: authorship 1169
type: Article
type: Continuant
doi: 10.1016/0300-483X(91)90145-Q
freetext keyword: Arsenic; Cadmium; Cardiotoxicity; Co-exposure; Glutathione; Lipid peroxidation; Metallothionen arsenic; cadmium; glutathione; metallothionein; animal experiment; article; cardiotoxicity; lipid peroxidation; male; nonhuman; priority journal; rat; tissue level; toxicokinetics; Animal; Arsenic; Cadmium; Drug Interactions; Glutathione; Heart; Lethal Dose 50; Lipid Peroxidation; Male; Metallothionein; Myocardium; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Animalia
related by: authorship 1171
most specific type: Article
abstract: Previously, we had shown that arsenic interacts with cadmium in rats; our results showed that the toxicity of a mixture of arsenic %2b cadmium cannot be predicted by the toxic mechanisms of the individual components. In this paper, we present further evidence about the interaction of arsenic and cadmium in rats. The results were: arsenic modified the 24 h-LD50 value of cadmium more clearly than cadmium did with the one of arsenic; based on the LD50 values, the mixtures we studied were more toxic than either metal alone. With single doses (As 10 mg/kg, Cd 2.6 mg/kg, and As 10 mg/kg %2b Cd 2.6 mg/kg) the mixture As %2b Cd was more toxic than each metal. At these doses, cadmium significantly induces the levels of glutathione, metallothionein, and lipid peroxidation in heart tissue, as compared to a saline group of rats. Arsenic incremented glutathione and lipid peroxidation at higher values than those obtained with cadmium. The mixture of As %2b Cd behaved as arsenic in the induction of lipid peroxidation and glutathione and like cadmium in metallothionein induction. Finally, rats treated with As %2b Cd had less Cd in liver than animals treated only with cadmium, and more As in heart tissue than rats treated only with arsenic. Our results give further evidence about the arsenic-cadmium interaction in rats, demonstrate the utility of employing different biomarkers in the study of chemical mixtures and indicate that heart tissue is affected not only by the mixture of As %2b Cd, but also by either metal alone. © 1991.
type: Generically Dependent Continuant
most specific type: Document
type: Information Content Entity
crisid: 275
type: Thing
type: Entity
related by: authorship 1168
date time value: article date 275
has publication venue: Toxicology
related by: authorship 1167
estado: published
chemicalscas: Arsenic, 7440-38-2; Cadmium, 7440-43-9; Glutathione, 70-18-8; Metallothionein, 9038-94-2
issue: 2
page end: 234
related by: authorship 1170
volume: 67
origen: scopus

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