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Norepinephrine homogeneously inhibits α-amino-3-hydroxyl-5-methyl-4- isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat
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page start: 1896
has publication venue: Neurochemical Research
volume: 34
freetext keyword: Auditory cortex; EPSC; Glutamate; Norepinephrine; Patch-clamp; PLC adrenergic receptor; alpha 1 adrenergic receptor; alpha amino 3 hydroxyl 5 methyl 4 isoxazole propionate; neurotransmitter; noradrenalin; propionic acid derivative; protein kinase C; unclassified drug; adrenergic activity; animal cell; animal experiment; animal model; article; auditory cortex; controlled study; depression; excitatory postsynaptic potential; kinetics; nonhuman; patch clamp; priority journal; rat; temporal cortex; whole cell; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Auditory Cortex; Excitatory Postsynaptic Potentials; Male; Norepinephrine; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Temporal Lobe; Rattus
type: Article
has funding vehicle: R01DC005986-04
related by: authorship_13538
date time value: article date 2279
origen: scopus
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related by: authorship_13539
type: Generically Dependent Continuant
issue: 11
type: Entity
pmid: 19357950
related by: authorship_13540
crisid: 2279
type: Continuant
chemicalscas: noradrenalin, 1407-84-7, 51-41-2; protein kinase C, 141436-78-4; Norepinephrine, 51-41-2; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, 77521-29-0
type: Document
abstract: The primary auditory cortex is subject to the modulation of numerous neurotransmitters including norepinephrine (NE), which has been shown to decrease cellular excitability by yet unclear mechanisms. We investigated the possibility that NE directly affects excitatory glutamatergic synapses. We found that bath applications of NE (20 μM) decreased glutamatergic excitatory post-synaptic currents (EPSCs) in all cortical layers. Changes in the kinetics of synaptic EPSCs, invariance of pair pulse ratio and of the coefficient-of-variation, together with the decrease of responses to pressure-application of AMPA (500 μM), indicated the postsynaptic nature of the adrenergic effect. Pharmacological experiments suggested that the NE-induced depression of EPSCs is caused by the activation of α1 adrenoceptors, PLC, and a Ca2%2b-independent PKC. We speculate that the decrease in temporal cortex excitability might promote a posterior-to-anterior shift in cortical activation together with a decrease in spontaneous background activity, resulting eventually in more effective sensory processing. © 2009 Springer Science%2bBusiness Media, LLC.
related by: authorship_13537
e iscopus: 2-s2.0-70349601757
page end: 1906
most specific type: Article
estado: published
most specific type: Document
doi: 10.1007/s11064-009-9966-z

Neurochemical Research
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publication venue for: Norepinephrine homogeneously inhibits α-amino-3-hydroxyl-5-methyl-4- isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat
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date: 2026-08-27T06:05:16
publisher: vivo
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label: RDF description of Norepinephrine homogeneously inhibits α-amino-3-hydroxyl-5-methyl-4- isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat - http://orbis.uaslp.mx/vivo/individual/scopus2278

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funding vehicle for: Norepinephrine homogeneously inhibits α-amino-3-hydroxyl-5-methyl-4- isoxazole-propionate- (AMPAR-) mediated currents in all layers of the temporal cortex of the rat

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