Document
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Consejo Nacional de Ciencia y Tecnología, CONACYT: PAPIIT 214608-19, 43533, 228586, 46-161-M
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type: BFO_0000020
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funding vehicle for: Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice

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Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice
freetext keyword: Dopamine; Nucleus accumbens; Stereotypy; Striatum; Tyrosine hydroxylase arsenic; dopamine; drinking water; messenger RNA; thioredoxin; tyrosine 3 monooxygenase; animal behavior; animal experiment; animal model; animal tissue; article; concentration response; controlled study; corpus striatum; dopaminergic system; down regulation; environmental exposure; female; gender; hyperactivity; hypothalamus; locomotion; male; mouse; neurochemistry; neurotoxicity; nonhuman; nucleus accumbens; oxidative stress; protein expression; reverse transcription polymerase chain reaction; Animals; Arsenites; Brain; Corpus Striatum; Cytosol; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Environmental Pollutants; Female; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Motor Activity; Sex Factors; Sodium Compounds; Thioredoxins; Time Factors; Tyrosine 3-Monooxygenase; Mus; Rodentia
related by: authorship_12853
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estado: published
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most specific type: Document
issue: 2
type: Article
type: Information Content Entity
page start: 169
pmid: 19121333
abstract: Arsenic (As) is a toxic metalloid widely present in the environment. Human exposure to As has been associated with the development of skin and internal organ cancers and cardiovascular disorders, among other diseases. A few studies report decreases in intelligence quotient (IQ), and sensory and motor alterations after chronic As exposure in humans. On the other hand, studies of rodents exposed to high doses of As have found alterations in locomotor activity, brain neurochemistry, behavioral tasks, and oxidative stress. In the present study both male and female C57Bl/6J mice were exposed to environmentally relevant doses of As such as 0.05, 0.5, 5.0, or 50 mg As/L of drinking water for 4 months, and locomotor activity was assessed every month. Male mice presented hyperactivity in the group exposed to 0.5 mg As/L and hypoactivity in the group exposed to 50 mg As/L after 4 months of As exposure, whereas female mice exposed to 0.05, 0.5, and 5.0 mg As/L exhibited hyperactivity in every monthly test during As exposure. Furthermore, striatal and hypothalamic dopamine content was decreased only in female mice. Also decreases in tyrosine hydroxylase (TH) and cytosolic thioredoxin (Trx-1) mRNA expression in striatum and nucleus accumbens were observed in male and female mice, respectively. These results indicate that chronic As exposure leads to gender-dependent alterations in dopaminergic markers and spontaneous locomotor activity, and down-regulation of the antioxidant capacity of the brain. © 2009 Elsevier Inc. All rights reserved.
type: Document
chemicalscas: arsenic, 7440-38-2; dopamine, 51-61-6, 62-31-7; thioredoxin, 52500-60-4; tyrosine 3 monooxygenase, 9036-22-0; Arsenites; Environmental Pollutants; Sodium Compounds; Thioredoxins, 52500-60-4; Tyrosine 3-Monooxygenase, 1.14.16.2; sodium arsenite, 13768-07-5
most specific type: Article
volume: 239
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: PAPIIT 214608-19, 43533, 228586, 46-161-M
related by: authorship_12848
related by: authorship_12850
doi: 10.1016/j.taap.2008.12.004
origen: scopus
related by: authorship_12849
related by: authorship_12852
type: Generically Dependent Continuant
date time value: article date 2182
has publication venue: Toxicology and Applied Pharmacology
crisid: 2182
type: Continuant
page end: 177
related by: authorship_12851

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individual
rights: termsOfUse
date: 2026-08-24T21:51:26
publisher: vivo
type: Document
label: RDF description of Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice - http://orbis.uaslp.mx/vivo/individual/scopus2181

Article
type: Class

Toxicology and Applied Pharmacology
type: Entity
type: Information Content Entity
publication venue for: Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice
type: Document
type: Thing
type: Periodical
type: Collection
type: Generically Dependent Continuant
type: Journal
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Information Content Entity
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