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Behavioural Brain Research
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publication venue for: Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
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Comisión Interministerial de Ciencia y Tecnología, CICYT: ADI-09
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funding vehicle for: Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning

Chronic stress induces dendritic atrophy in the rat medial geniculate nucleus: Effects on auditory conditioning
abstract: Chronic stress induces dendritic atrophy in the inferior colliculus (IC, auditory mesencephalon) and impairs auditory avoidance conditioning. The aim of this study was to determine in Golgi preparations and in cued fear conditioning whether stress affects other auditory components, like the thalamic medial geniculate nucleus (MG) or the posterior thalamic nucleus (PO), in Sprague-Dawley rats. Chronic restraint stress produced a significant dendritic atrophy in the MG (stress: 407 ± 55 μm; control: 808 ± 120 μm; p < 0.01) but did not affect auditory fear conditioning. The last result was in apparent contrast with the fact that stress impairs both the acquisition of auditory avoidance conditioned responses and the dendritic structure in two major nuclei of the auditory system. In order to analyze this disagreement, we investigated whether the stress-related freezing to tone occurring in the fear conditioning protocol corresponded to a conditioned or an unconditioned fear response, using changes in tone instead of light throughout conditioning trials. Chronic stress significantly enhanced visual fear conditioning in stressed animals compared to controls (stress: 58.9 ± 8.42%25, control: 23.31 ± 8.01%25; p < 0.05), but this fear enhancement was related to unconditioned fear. Conversely, chronic stress did not affect the morphology of the PO (subserving both auditory and somatosensory information) or the corresponding auditory and somatosensory unconditioned responses (acoustic startle response and escape behavior). Our results suggest that the auditory conditioned stimulus can be processed in part independently of the IC and MG in the stressed animals, and sent to the amygdala via the PO inducing unconditioned fear. Comparable alterations could be produced in major depression. © 2009 Elsevier B.V. All rights reserved.
doi: 10.1016/j.bbr.2009.04.024
crisid: 2137
type: Information Content Entity
related by: authorship_12645
related by: authorship_12641
type: Document
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pmid: 19397934
estado: published
related by: authorship_12647
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related by: authorship_12644
page end: 96
freetext keyword: Dendritic atrophy; Depression; Fear; Geniculate; Stress animal experiment; animal model; animal tissue; article; auditory discrimination; auditory response; auditory stimulation; auditory system; avoidance behavior; brain atrophy; chronic stress; conditioning; controlled study; dendritic cell; escape behavior; fear; freezing; geniculate nucleus; Golgi complex; immobilization stress; major depression; male; nonhuman; priority journal; rat; somatosensory stimulation; startle reflex; thalamus posterior nucleus; Acoustic Stimulation; Animals; Auditory Perception; Conditioning, Classical; Dendrites; Escape Reaction; Fear; Freezing Reaction, Cataleptic; Geniculate Bodies; Male; Neurons; Photic Stimulation; Posterior Thalamic Nuclei; Random Allocation; Rats; Rats, Sprague-Dawley; Restraint, Physical; Startle Reaction; Stress, Psychological; Visual Perception
type: Article
most specific type: Document
related by: authorship_12649
related by: authorship_12646
has funding vehicle: Comisión Interministerial de Ciencia y Tecnología, CICYT: ADI-09
related by: authorship_12642
type: Generically Dependent Continuant
volume: 203
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page start: 88
most specific type: Article
related by: authorship_12648
date time value: article date 2137
e iscopus: 2-s2.0-67349115206
has publication venue: Behavioural Brain Research
related by: authorship_12643
issue: 1
origen: scopus

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date: 2026-08-27T05:52:58
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