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date: 2026-08-28T01:50:26
publisher: vivo
type: Document
label: RDF description of Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: A dynamic spatial model - http://orbis.uaslp.mx/vivo/individual/scopus2117

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Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: A dynamic spatial model
type: Thing
date time value: article date 2118
abstract: Background: Dynamical models are instrumental for exploring the way information required to generate robust developmental patterns arises from complex interactions among genetic and non-genetic factors. We address this fundamental issue of developmental biology studying the leaf and root epidermis of Arabidopsis. We propose an experimentally-grounded model of gene regulatory networks (GRNs) that are coupled by protein diffusion and comprise a meta-GRN implemented on cellularised domains. Results: Steady states of the meta-GRN model correspond to gene expression profiles typical of hair and non-hair epidermal cells. The simulations also render spatial patterns that match the cellular arrangements observed in root and leaf epidermis. As in actual plants, such patterns are robust in the face of diverse perturbations. We validated the model by checking that it also reproduced the patterns of reported mutants. The meta-GRN model shows that interlinked sub-networks contribute redundantly to the formation of robust hair patterns and permits to advance novel and testable predictions regarding the effect of cell shape, signalling pathways and additional gene interactions affecting spatial cell-patterning. Conclusion: The spatial meta-GRN model integrates available experimental data and contributes to further understanding of the Arabidopsis epidermal system. It also provides a systems biology framework to explore the interplay among sub-networks of a GRN, cell-to-cell communication, cell shape and domain traits, which could help understanding of general aspects of patterning processes. For instance, our model suggests that the information needed for cell fate determination emerges from dynamic processes that depend upon molecular components inside and outside differentiating cells, suggesting that the classical distinction of lineage versus positional cell differentiation may be instrumental but rather artificial. It also suggests that interlinkage of nonlinear and redundant…
freetext keyword: Arabidopsis; gibberellic acid; gibberellin; vegetable protein; Arabidopsis; article; biological model; cell communication; cell proliferation; cell shape; cytology; gene expression profiling; gene regulatory network; genetics; metabolism; mutation; phenotype; plant epidermis; plant leaf; plant root; reproducibility; signal transduction; upregulation; Arabidopsis; Cell Communication; Cell Proliferation; Cell Shape; Gene Expression Profiling; Gene Regulatory Networks; Gibberellins; Models, Biological; Mutation; Phenotype; Plant Epidermis; Plant Leaves; Plant Proteins; Plant Roots; Reproducibility of Results; Signal Transduction; Up-Regulation
type: Continuant
pmid: 19014692
type: Document
doi: 10.1186/1752-0509-2-98
volume: 2
most specific type: Article
crisid: 2118
type: Article
has publication venue: BMC Systems Biology
type: Entity
type: Generically Dependent Continuant
artnum: 98
related by: authorship_12558
e iscopus: 2-s2.0-57949104109
most specific type: Document
accesstype: All Open Access, Gold, Green
estado: published
related by: authorship_12560
type: Information Content Entity
related by: authorship_12561
chemicalscas: gibberellic acid, 77-06-5; Gibberellins; Plant Proteins; gibberellic acid, 77-06-5
origen: scopus
related by: authorship_12559

BMC Systems Biology
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publication venue for: Interlinked nonlinear subnetworks underlie the formation of robust cellular patterns in Arabidopsis epidermis: A dynamic spatial model
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type: Generically Dependent Continuant
type: Periodical
type: Continuant
type: Document