Journal of Rheumatology
type: Periodical
type: Information Content Entity
type: Journal
type: Thing
type: Document
type: Collection
type: Continuant
type: Entity
publication venue for: Natural killer cell activity in dermatomyositis-polymyositis
type: Generically Dependent Continuant

Document
type: Class

Continuant
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Natural killer cell activity in dermatomyositis-polymyositis
freetext keyword: interleukin 2; clinical article; dermatomyositis; disease activity; etiology; human; muscle; natural killer cell; polymyositis; priority journal; Adolescent; Adult; Cytotoxicity, Immunologic; Dermatomyositis; Female; Human; Interleukin-2; Killer Cells, Natural; Male; Middle Age; Myositis; Support, Non-U.S. Gov't
has publication venue: Journal of Rheumatology
most specific type: Document
issue: 2
type: Generically Dependent Continuant
type: Thing
related by: authorship 920
pmid: 3496455
abstract: We examined the baseline natural killer (NK) function and its modulation by interleukin-2 (IL-2) in 16 patients with dermatomyositis/polymyositis (DM/PM). Patients with active untreated disease had low baseline NK activity, while in patients with inactive and untreated disease, it was akin to the controls. Patients' cells with low NK activity responded less to IL-2 than those with normal NK activity. Studies at the single cell level revealed decreased target binding and killing cells with a normal recycling capacity. Our findings indicate an association between disease activity and decreased NK function in patients with DM/PM that could play a role in its association with malignancy.
type: Entity
volume: 14
origen: scopus
page end: 310
date time value: article date 203
type: Document
type: Article
type: Continuant
crisid: 203
type: Information Content Entity
e iscopus: 2-s2.0-0023238070
most specific type: Article
page start: 307
chemicalscas: interleukin 2, 85898-30-2; Interleukin-2
related by: authorship 919
related by: authorship 918
estado: published
abstract: We examined the baseline natural killer (NK) function and its modulation by interleukin-2 (IL-2) in 16 patients with dermatomyositis/polymyositis (DM/PM). Patients with active untreated disease had low baseline NK activity, while in patients with inactive and untreated disease, it was akin to the controls. Patients%27 cells with low NK activity responded less to IL-2 than those with normal NK activity. Studies at the single cell level revealed decreased target binding and killing cells with a normal recycling capacity. Our findings indicate an association between disease activity and decreased NK function in patients with DM/PM that could play a role in its association with malignancy.

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RDF description of Natural killer cell activity in dermatomyositis-polymyositis - http://orbis.uaslp.mx/vivo/individual/scopus202
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date: 2026-08-24T21:51:23
publisher: vivo
type: Document

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