Document
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International Journal of Leprosy
type: Journal
type: Entity
type: Continuant
type: Generically Dependent Continuant
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type: Collection
type: Information Content Entity
publication venue for: Thalidomide. Effect on T cell subsets as a possible mechanism of action
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type: Document

Continuant
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Entity
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Generically Dependent Continuant
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RDF description of Thalidomide. Effect on T cell subsets as a possible mechanism of action - http://orbis.uaslp.mx/vivo/individual/scopus180
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date: 2026-08-24T21:50:50
publisher: vivo
type: Document

Article
type: Class

Thalidomide. Effect on T cell subsets as a possible mechanism of action
chemicalscas: colchicine, 64-86-8; prednisone, 53-03-2; thalidomide, 50-35-1; Thalidomide, 50-35-1
freetext keyword: colchicine; prednisone; thalidomide; blood and hemopoietic system; cellular immunity; clinical article; drug efficacy; drug therapy; erythema nodosum leprosum; helper cell; human; leprosy; oral drug administration; priority journal; t lymphocyte subpopulation; therapy; Adolescent; Behcet Syndrome; Erythema Nodosum; Female; Humans; Leprosy; T-Lymphocytes; Thalidomide
type: Document
estado: published
related by: authorship 850
related by: authorship 847
type: Information Content Entity
date time value: article date 181
type: Thing
type: Article
type: Entity
type: Generically Dependent Continuant
issue: 2
type: Continuant
page start: 201
abstract: Thalidomide is the drug of choice in the erythema nodosum leprosum (ENL) type of lepra reaction. Lately it has been used successfully in other diseases, such as discoid lupus erythematosus, actinic prurigo, Behcet's disease, etc. However, its mechanism of action remains unknown. In patients for whom thalidomide provided relief in their disorder, the proportions of T lymphocytes and their subsets in peripheral blood were assessed by means of monoclonal antibodies. Three lepromatous leprosy patients with ENL had their T helper populations significantly increased after thalidomide therapy. A 14-year-old girl with Behcet's syndrome showed a consistent decrease in Ia%2b cells throughout her three-month course of thalidomide therapy. The same findings were observed in two patients with the actinic prurigo type of polymorphous light eruption. From these results, we conclude that thalidomide may act as an immunomodulating agent on T cell subsets
page end: 205
related by: authorship 849
e iscopus: 2-s2.0-0021926865
volume: 53
most specific type: Document
abstract: Thalidomide is the drug of choice in the erythema nodosum leprosum (ENL) type of lepra reaction. Lately it has been used successfully in other diseases, such as discoid lupus erythematosus, actinic prurigo, Behcet%27s disease, etc. However, its mechanism of action remains unknown. In patients for whom thalidomide provided relief in their disorder, the proportions of T lymphocytes and their subsets in peripheral blood were assessed by means of monoclonal antibodies. Three lepromatous leprosy patients with ENL had their T helper populations significantly increased after thalidomide therapy. A 14-year-old girl with Behcet%27s syndrome showed a consistent decrease in Ia cells throughout her three-month course of thalidomide therapy. The same findings were observed in two patients with the actinic prurigo type of polymorphous light eruption. From these results, we conclude that thalidomide may act as an immunomodulating agent on T cell subsets
most specific type: Article
pmid: 3874920
crisid: 181
related by: authorship 851
related by: authorship 848
has publication venue: International Journal of Leprosy
origen: scopus

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