Document
Consejo Nacional de Ciencia y Tecnología, CONACYT: 158330
Generically Dependent Continuant
RDF description of Fuzzy-based controller for glucose regulation in type-1 diabetic patients by subcutaneous route - http://orbis.uaslp.mx/vivo/individual/scopus1680
Article
IEEE Transactions on Biomedical Engineering
Information Content Entity
This paper presents an advisory/control algorithm for a type-1 diabetes mellitus (TIDM) patient under an intensive insulin treatment based on a multiple daily injections regimen (MDIR). The advisory/control algorithm incorporates expert knowledge about the treatment of this disease by using Mamdani-type fuzzy logic controllers to regulate the blood glucose level (BGL). The overall control strategy is based on a two-loop feedback strategy to overcome the variability in the glucose-insulin dynamics from patient to patient. An inner-loop provides the amount of both rapid/short and intermediate/long acting insulin (RSAI and ILAI) formulations that are programmed in a three-shots daily basis before meals. The combined preparation is then injected by the patient through a subcutaneous route. Meanwhile, an outer-loop adjusts the maximum amounts of insulin provided to the patient in a time-scale of days. The outer-loop controller aims to work as a supervisor of the inner-loop controller. Extensive closed-loop simulations are illustrated, using a detailed compartmental model of the insulin-glucose dynamics in a TIDM patient with meal intake. © 2006 IEEE.
Diabetes mellitus; Fuzzy control; Glucose regulation; Intensive insulin therapy Blood glucose level (BGL); Diabetes mellitus; Glucose regulation; Intensive insulin therapy; Algorithms; Blood; Computer simulation; Diseases; Glucose; Mathematical models; Patient treatment; Fuzzy control; glucose; insulin; adult; algorithm; article; compartment model; feedback system; food intake; glucose blood level; glycemic control; human; insulin dependent diabetes mellitus; insulin release; insulin treatment; male; mathematical computing; mathematical model; meal; methodology; Algorithms; Blood Glucose; Computer Simulation; Diabetes Mellitus, Type 1; Drug Therapy, Computer-Assisted; Feedback; Humans; Injections, Subcutaneous; Insulin; Models, Biological
Fuzzy-based controller for glucose regulation in type-1 diabetic patients by subcutaneous route