Document
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Plant Cell
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type: Periodical
type: Thing
publication venue for: A gene regulatory network model for cell-fate determination during Arabidopsis thaliana flower development that is robust and recovers experimental gene expression profiles
type: Generically Dependent Continuant
type: Document
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Generically Dependent Continuant
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individual
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date: 2026-08-28T01:53:12
publisher: vivo
type: Document
label: RDF description of A gene regulatory network model for cell-fate determination during Arabidopsis thaliana flower development that is robust and recovers experimental gene expression profiles - http://orbis.uaslp.mx/vivo/individual/scopus1366

Article
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Information Content Entity
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A gene regulatory network model for cell-fate determination during Arabidopsis thaliana flower development that is robust and recovers experimental gene expression profiles
type: Article
estado: published
related by: authorship 8089
page end: 2939
abstract: Flowers are icons in developmental studies of complex structures. The vast majority of 250,000 angiosperm plant species have flowers with a conserved organ plan bearing sepals, petals, stamens, and carpels in the center. The combinatorial model for the activity of the so-called ABC homeotic floral genes has guided extensive experimental studies in Arabidopsis thaliana and many other plant species. However, a mechanistic and dynamical explanation for the ABC model and prevalence among flowering plants is lacking. Here, we put forward a simple discrete model that postulates logical rules that formally summarize published ABC and non-ABC gene interaction data for Arabidopsis floral organ cell fate determination and integrates this data into a dynamic network model. This model shows that all possible initial conditions converge to few steady gene activity states that match gene expression profiles observed experimentally in primordial floral organ cells of wild-type and mutant plants. Therefore, the network proposed here provides a dynamical explanation for the ABC model and shows that precise signaling pathways are not required to restrain cell types to those found in Arabidopsis, but these are rather determined by the overall gene network dynamics. Furthermore, we performed robustness analyses that clearly show that the cell types recovered depend on the network architecture rather than on specific values of the model's gene interaction parameters. These results support the hypothesis that such a network constitutes a developmental module, and hence provide a possible explanation for the overall conservation of the ABC model and overall floral plan among angiosperms. In addition, we have been able to predict the effects of differences in network architecture between Arabidopsis and Petunia hybrida. © 2004 American Society of Plant Biologists.
freetext keyword: Cells; Mathematical models; Mutagenesis; Plants (botany); Arabidopsis thaliana; Gene regulatory network model; Petunia hybrida; Species; Genes; Angiosperms; Cells; Flowers; Genes; Mathematical Analysis; Mutation; Arabidopsis; Arabidopsis thaliana; Magnoliophyta; Petunia; Petunia x hybrida; Arabidopsis protein; Arabidopsis; article; biological model; cell differentiation; cell lineage; cytology; flower; gene expression profiling; gene expression regulation; genetics; growth, development and aging; metabolism; methodology; molecular evolution; mutation; nucleotide sequence; Petunia; signal transduction; Arabidopsis; Arabidopsis Proteins; Cell Differentiation; Cell Lineage; Conserved Sequence; Evolution, Molecular; Flowers; Gene Expression Profiling; Gene Expression Regulation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Models, Genetic; Mutation; Petunia; Signal Transduction
type: Document
accesstype: All Open Access, Bronze, Green
type: Information Content Entity
most specific type: Article
related by: authorship 8090
volume: 16
origen: scopus
page start: 2923
e iscopus: 2-s2.0-16644389406
most specific type: Document
type: Thing
type: Entity
abstract: Flowers are icons in developmental studies of complex structures. The vast majority of 250,000 angiosperm plant species have flowers with a conserved organ plan bearing sepals, petals, stamens, and carpels in the center. The combinatorial model for the activity of the so-called ABC homeotic floral genes has guided extensive experimental studies in Arabidopsis thaliana and many other plant species. However, a mechanistic and dynamical explanation for the ABC model and prevalence among flowering plants is lacking. Here, we put forward a simple discrete model that postulates logical rules that formally summarize published ABC and non-ABC gene interaction data for Arabidopsis floral organ cell fate determination and integrates this data into a dynamic network model. This model shows that all possible initial conditions converge to few steady gene activity states that match gene expression profiles observed experimentally in primordial floral organ cells of wild-type and mutant plants. Therefore, the network proposed here provides a dynamical explanation for the ABC model and shows that precise signaling pathways are not required to restrain cell types to those found in Arabidopsis, but these are rather determined by the overall gene network dynamics. Furthermore, we performed robustness analyses that clearly show that the cell types recovered depend on the network architecture rather than on specific values of the model%27s gene interaction parameters. These results support the hypothesis that such a network constitutes a developmental module, and hence provide a possible explanation for the overall conservation of the ABC model and overall floral plan among angiosperms. In addition, we have been able to predict the effects of differences in network architecture between Arabidopsis and Petunia hybrida. © 2004 American Society of Plant Biologists.
chemicalscas: Arabidopsis Proteins
type: Continuant
crisid: 1367
date time value: article date 1367
pmid: 15486106
issue: 11
type: Generically Dependent Continuant
has publication venue: Plant Cell
related by: authorship 8091
doi: 10.1105/tpc.104.021725