Cluster headache: an update on clinical features, epidemiology, pathophysiology, diagnosis, and treatment
type: Continuant
freetext keyword: cluster headache; diagnosis; differential diagnosis; epidemiology; risk factors
type: Document
estado: published
artnum: 1373528
date time value: review date 12538
crisid: 12538
type: Generically Dependent Continuant
abstract: Cluster headache (CH) is one of the worst primary headaches that remain underdiagnosed and inappropriately treated. There are recent advances in the understanding of this disease and available treatments. This paper aims to review CH%27s recent clinical and pathophysiological findings, diagnosis, and treatment. We performed a narrative literature review on the socio-demographics, clinical presentations, pathophysiological findings, and diagnosis and treatment of CH. CH affects 0.1%25 of the population with an incidence of 2.07–9.8/100,00 person-years-habitants, a mean prevalence of 53/100,000 inhabitants (3–150/100,000 inhabitants). The male-to-female ratio remains inconclusive, as the ratio of 4.3:1 has recently been modified to 1.3–2.6, possibly due to previous misdiagnosis in women. Episodic presentation is the most frequent (80%25). It is a polygenetic and multifactorial entity that involves dysfunction of the trigeminovascular system, the trigeminal autonomic reflex, and the hypothalamic networks. An MRI of the brain is mandatory to exclude secondary etiologies. There are effective and safe pharmacological treatments oxygen, sphenopalatine, and great occipital nerve block, with the heterogeneity of clinical trial designs for patients with CH divided into acute, transitional, or bridge treatment (prednisone) and preventive interventions. In conclusion, CH remains underdiagnosed, mainly due to a lack of awareness within the medical community, frequently causing a long delay in reaching a final diagnosis. Recent advances in understanding the principal risk factors and underlying pathophysiology exist. There are new therapeutic possibilities that are effective for CH. Indeed, a better understanding of this challenging pathology will continue to be a subject of research, study, and discoveries in its diagnostic and therapeutic approach. 2024 San-Juan, Velez-Jimenez, Hoffmann, Martínez-Mayorga, Melo-Carrillo, Rodríguez-Leyva, García, Collado-Ortiz, Chiquete, Gudiño-C…
type: Information Content Entity
type: Entity
doi: 10.3389/fpain.2024.1373528
accesstype: Open Access
type: Thing
e iscopus: 2-s2.0-85188256251
volume: 5
most specific type: Review
type: Review
has publication venue: Frontiers in Pain Research
has funding vehicle: Bristol-Myers Squibb, BMS
type: Article

Bristol-Myers Squibb, BMS
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type: BFO_0000020
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type: Grant
type: Continuant
funding vehicle for: Cluster headache: an update on clinical features, epidemiology, pathophysiology, diagnosis, and treatment

Document
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Continuant
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Entity
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Review
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Generically Dependent Continuant
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RDF description of Cluster headache: an update on clinical features, epidemiology, pathophysiology, diagnosis, and treatment - http://orbis.uaslp.mx/vivo/individual/scopus12537
rights: termsOfUse
date: 2026-08-27T18:18:52
publisher: vivo
type: Document

Article
type: Class

Frontiers in Pain Research
type: Journal
type: Document
type: Collection
type: Information Content Entity
type: Entity
type: Continuant
type: Thing
type: Periodical
type: Generically Dependent Continuant
publication venue for: Cluster headache: an update on clinical features, epidemiology, pathophysiology, diagnosis, and treatment

Information Content Entity
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