Document
type: Class

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
artnum: 101136
abstract: Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mechanisms and, if deregulated, they can lead to cancer development and progression. Recently, it has been described that lncRNAs are susceptible to form gene fusions with mRNAs or other lncRNAs, breaking the paradigm of gene fusions consisting mainly of protein-coding genes. However, their biological significance in the tumor phenotype is still uncertain. Therefore, their recent identification opens a new line of research to study their biological role in tumorigenesis, and their potential as biomarkers with clinical relevance or as therapeutic targets. The present study aimed to review the lncRNA fusions identified so far and to know which of them have been associated with a potential function. We address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window in cancer.
type: Article
type: Document
issue: 3
has publication venue: Genes and Diseases
estado: published
type: Entity
type: Generically Dependent Continuant
volume: 11
crisid: 12525
date time value: review date 12525
accesstype: Open Access
has funding vehicle: Instituto de Salud Pública; Universidad Veracruzana, UV
doi: 10.1016/j.gendis.2023.101136
type: Review
e iscopus: 2-s2.0-85182015725
freetext keyword: Cancer; Gene fusions; lncRNAs; ncRNAs; Therapy biological marker; long non coding RNA PVT1; long untranslated RNA; messenger RNA; unclassified drug; cancer therapy; carcinogenesis; cell proliferation; fusion gene; gene; gene function; gene mutation; human; medical research; oncogene; protein coding gene; protein tertiary structure; pseudogene; Review; therapeutic index
type: Information Content Entity
type: Continuant
most specific type: Review
type: Thing

Continuant
type: Class

Entity
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Review
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Generically Dependent Continuant
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RDF description of Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer - http://orbis.uaslp.mx/vivo/individual/scopus12524
rights: termsOfUse
date: 2026-08-28T03:44:54
publisher: vivo
type: Document

Article
type: Class

Information Content Entity
type: Class

Genes and Diseases
type: Information Content Entity
type: Document
type: Generically Dependent Continuant
publication venue for: Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
type: Journal
type: Entity
type: Collection
type: Continuant
type: Periodical
type: Thing

Instituto de Salud Pública; Universidad Veracruzana, UV
type: Relationship
type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer