Document
type: Class

Synthesis of Novel Fluoro Phenyl Triazoles Via Click Chemistry with or without Microwave Irradiation and their Evaluation as Anti-proliferative Agents in SiHa Cells
type: Continuant
crisid: 11917
page end: 570
related by: authorship_74152
abstract: Aims: Perform the synthesis of novel fluoro phenyl triazoles via click chemistry with or without microwave irradiation and their evaluation as anti-proliferative agents in SiHa cells. Background: Triazoles are heterocyclic compounds containing a five-member ring with two carbon and three nitrogen atoms. They are of great importance since many of them have shown to have biological activity as antifungal, antiviral, antibacterial, anti-HIV, anti-tuberculosis, vasodilator, and anticancer agents. Objectives: Synthesize novel fluoro phenyl triazoles via click chemistry and evaluate their anti-proliferative activity. Methods: First, several fluorophenyl azides were prepared. Reacting these aryl azides with phenylacetylene in the presence of Cu(I) catalyst, the corresponding fluoro phenyl triazoles were obtained by two methodologies, stirring at room temperature and under microwave irradiation at 40ºC. In addition, their antiproliferative activity was evaluated in cervical cancer SiHa cells. Results: Fluoro phenyl triazoles were obtained within minutes by means of microwave irradiation. The compound 3f, containing two fluorine atoms next to the carbon connected to the triazole ring, was the most potent among the fluoro phenyl triazoles tested in this study. Interestingly, the addition of a fluorine atom to the phenyl triazole structure in a specific site increases its antiproliferative effect as compared to parent phenyl triazole 3a without a fluorine atom. Conclusion: Several fluoro phenyl triazoles were obtained by reacting fluoro phenyl azides with phenylacetylene in the presence of copper sulphate, sodium ascorbate and phenanthroline. Preparation of these triazoles with MW irradiation represents a better methodology since they are obtained within minutes and higher yields of cleaner compounds are obtained. In terms of biological studies, the proximity between fluorine atom and triazole ring increases its biological activity.
related by: authorship_74153
type: Document
freetext keyword: antiproliferative effect; biological; click chemistry; cytotoxic activity; Fluoro phenyl triazoles; microwave
volume: 21
type: Entity
page start: 559
related by: authorship_74157
type: Article
most specific type: Document
related by: authorship_74154
related by: authorship_74155
estado: published
has publication venue: Current Organic Synthesis
e iscopus: 2-s2.0-85175845599
related by: authorship_74158
related by: authorship_74151
type: Thing
type: Information Content Entity
date time value: article date 11917
related by: authorship_74156
doi: 10.2174/1570179420666230420084000
most specific type: Article
issue: 4
type: Generically Dependent Continuant
has funding vehicle: United Nations Educational, Scientific and Cultural Organization, UNESCO; Academy of Medical Sciences, (G2022); Consejo Nacional de Humanidades, Ciencias y Tecnologías, Conahcyt, (CVU 1007105)

Continuant
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Entity
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Generically Dependent Continuant
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Current Organic Synthesis
publication venue for: Synthesis of Novel Fluoro Phenyl Triazoles Via Click Chemistry with or without Microwave Irradiation and their Evaluation as Anti-proliferative Agents in SiHa Cells
type: Periodical
type: Entity
type: Journal
type: Thing
type: Continuant
type: Document
type: Generically Dependent Continuant
type: Information Content Entity
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individual
rights: termsOfUse
date: 2026-08-28T02:21:18
publisher: vivo
type: Document
label: RDF description of Synthesis of Novel Fluoro Phenyl Triazoles Via Click Chemistry with or without Microwave Irradiation and their Evaluation as Anti-proliferative Agents in SiHa Cells - http://orbis.uaslp.mx/vivo/individual/scopus11916

Article
type: Class

Information Content Entity
type: Class

United Nations Educational, Scientific and Cultural Organization, UNESCO; Academy of Medical Sciences, (G2022); Consejo Nacional de Humanidades, Ciencias y Tecnologías, Conahcyt, (CVU 1007105)
type: Relationship
type: BFO_0000020
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type: Thing
type: Grant
type: Continuant
funding vehicle for: Synthesis of Novel Fluoro Phenyl Triazoles Via Click Chemistry with or without Microwave Irradiation and their Evaluation as Anti-proliferative Agents in SiHa Cells