Document
type: Class

Continuant
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Entity
type: Class

Journal of Leukocyte Biology
type: Periodical
type: Collection
type: Generically Dependent Continuant
type: Continuant
type: Journal
type: Entity
type: Thing
type: Information Content Entity
type: Document
publication venue for: Effect of pentoxifylline on polarization and migration of human leukocytes

Generically Dependent Continuant
type: Class

RDF description of Effect of pentoxifylline on polarization and migration of human leukocytes - http://orbis.uaslp.mx/vivo/individual/scopus1084
rights: termsOfUse
date: 2026-08-24T21:50:51
publisher: vivo
type: Document

Article
type: Class

Information Content Entity
type: Class

Effect of pentoxifylline on polarization and migration of human leukocytes
manufactures: Hoechst, Germany
related by: authorship 6254
crisid: 1085
chemicalscas: intercellular adhesion molecule 1, 126547-89-5; interleukin 8, 114308-91-7; pentoxifylline, 6493-05-6; Cell Adhesion Molecules; Pentoxifylline, 6493-05-6; Phosphodiesterase Inhibitors
related by: authorship 6256
type: Entity
most specific type: Document
has publication venue: Journal of Leukocyte Biology
related by: authorship 6258
origen: scopus
pmid: 11927644
type: Continuant
issue: 4
volume: 71
type: Document
related by: authorship 6253
type: Generically Dependent Continuant
type: Thing
type: Article
page start: 588
abstract: Leukocyte polarization has a key role in the induction and effector phases of immune response. We assessed the effect of pentoxifylline (PTX) on the polarization and migration of human lymphocytes and neutrophils. A dose-dependent, inhibitory effect on the polarization of lymphoid cells induced by chemokines or IL-15 was found. In addition, PTX interfered with the chemotaxis of peripheral blood T cells and T lymphoblasts. A similar effect was observed on the transendothelial migration of these cells. In addition, the polarization of neutrophils, its adherence to endothelium, and their transendothelial migration, induced by different stimuli, were inhibited by PTX. By contrast, this drug had only a mild effect on endothelial cells and a partial inhibition on the induction of ICAM-1 expression by TNF-α. The inhibitory effect of PTX on leukocyte polarization and extravasation may contribute significantly to the anti-inflammatory and immunoregulatory activity of this drug.
related by: authorship 6257
date time value: article date 1085
most specific type: Article
estado: published
related by: authorship 6255
page end: 596
e iscopus: 2-s2.0-0036554332
freetext keyword: Chemokines; Chemotaxis; Neutrophils; T lymphocytes chemokine; complement component C5a; formylmethionylleucylphenylalanine; intercellular adhesion molecule 1; interleukin 8; monoclonal antibody; monocyte chemotactic protein 1; pentoxifylline; RANTES; recombinant interleukin 15; stromal cell derived factor 1; tumor necrosis factor alpha; antiinflammatory activity; article; cell migration; chemotaxis; controlled study; dose response; flow cytometry; human; human cell; immunoregulation; leukocyte migration; mononuclear cell; polarization; priority journal; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; Leukocytes; Lymphocytes; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors
related by: authorship 6259
type: Information Content Entity