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RDF description of Effect of pentoxifylline on polarization and migration of human leukocytes - http://orbis.uaslp.mx/vivo/individual/scopus1084
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Effect of pentoxifylline on polarization and migration of human leukocytes
intercellular adhesion molecule 1, 126547-89-5; interleukin 8, 114308-91-7; pentoxifylline, 6493-05-6; Cell Adhesion Molecules; Pentoxifylline, 6493-05-6; Phosphodiesterase Inhibitors
Leukocyte polarization has a key role in the induction and effector phases of immune response. We assessed the effect of pentoxifylline (PTX) on the polarization and migration of human lymphocytes and neutrophils. A dose-dependent, inhibitory effect on the polarization of lymphoid cells induced by chemokines or IL-15 was found. In addition, PTX interfered with the chemotaxis of peripheral blood T cells and T lymphoblasts. A similar effect was observed on the transendothelial migration of these cells. In addition, the polarization of neutrophils, its adherence to endothelium, and their transendothelial migration, induced by different stimuli, were inhibited by PTX. By contrast, this drug had only a mild effect on endothelial cells and a partial inhibition on the induction of ICAM-1 expression by TNF-α. The inhibitory effect of PTX on leukocyte polarization and extravasation may contribute significantly to the anti-inflammatory and immunoregulatory activity of this drug.
Chemokines; Chemotaxis; Neutrophils; T lymphocytes chemokine; complement component C5a; formylmethionylleucylphenylalanine; intercellular adhesion molecule 1; interleukin 8; monoclonal antibody; monocyte chemotactic protein 1; pentoxifylline; RANTES; recombinant interleukin 15; stromal cell derived factor 1; tumor necrosis factor alpha; antiinflammatory activity; article; cell migration; chemotaxis; controlled study; dose response; flow cytometry; human; human cell; immunoregulation; leukocyte migration; mononuclear cell; polarization; priority journal; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Polarity; Endothelium, Vascular; Humans; Leukocytes; Lymphocytes; Neutrophils; Pentoxifylline; Phosphodiesterase Inhibitors