Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer
type: Thing
related by: authorship_71273
e iscopus: 2-s2.0-85140573996
freetext keyword: breast cancer; nanomolecule; sulforaphane antineoplastic agent; butane; isothiocyanic acid; phosphatidylinositol 3 kinase; protein kinase B; target of rapamycin kinase; thiocyanic acid derivative; water; breast tumor; female; human; nanomedicine; Anticarcinogenic Agents; Breast Neoplasms; Butanes; Female; Humans; Isothiocyanates; Nanomedicine; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Thiocyanates; TOR Serine-Threonine Kinases; Water
type: Information Content Entity
type: Document
crisid: 10587
has publication venue: Medicina (Lithuania)
most specific type: Review
related by: authorship_71275
most specific type: Document
doi: 10.3390/medicina58101377
origen: scopus
type: Entity
date time value: review date 10587
type: Article
estado: published
type: Continuant
issue: 10
pmid: 36295538
related by: authorship_71274
volume: 58
type: Generically Dependent Continuant
abstract: Because cancer is a multifactorial disease, it is difficult to identify the specific agents responsible for the disease’s progression and development, but lifestyle and diet have been shown to play a significant role. Diverse natural compounds are demonstrating efficacy in the development of novel cancer therapies, including sulforaphane (1-isothiocyanate-4-(methylsulfinyl)butane), a compound found in broccoli and other cruciferous vegetables that promotes key biological processes such as apoptosis, cell cycle arrest, autophagy, and suppression of key signalling pathways such as the PI3K/AKT/mTOR pathway in breast cancer cells. However, one of the primary challenges with sulforaphane treatment is its low solubility in water and oral bioavailability. As a consequence, several investigations were conducted using this component complexed in nanoparticles, which resulted in superior outcomes when combined with chemotherapy drugs. In this study, we discuss the properties and benefits of sulforaphane in cancer therapy, as well as its ability to form complexes with nanomolecules and chemotherapeutic agents that synergize the antitumour response in breast cancer cells. © 2022 by the authors.
type: Review
chemicalscas: butane, 106-97-8; isothiocyanic acid, 3129-90-6, 71048-69-6; phosphatidylinositol 3 kinase, 115926-52-8; protein kinase B, 148640-14-6; target of rapamycin kinase, 171715-28-9; water, 7732-18-5; Anticarcinogenic Agents; Butanes; Isothiocyanates; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Thiocyanates; TOR Serine-Threonine Kinases; Water
accesstype: All Open Access, Gold
artnum: 1377
related by: authorship_71276

Document
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Review
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Generically Dependent Continuant
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RDF description of Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer - http://orbis.uaslp.mx/vivo/individual/scopus10586
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date: 2026-08-28T02:06:43
publisher: vivo
type: Document

Article
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Information Content Entity
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Medicina (Lithuania)
type: Information Content Entity
type: Generically Dependent Continuant
type: Document
type: Collection
type: Entity
type: Periodical
type: Continuant
publication venue for: Molecular Pathways Related to Sulforaphane as Adjuvant Treatment: A Nanomedicine Perspective in Breast Cancer
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type: Thing