Document
type: Class

Continuant
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Entity
type: Class

Review
type: Class

Generically Dependent Continuant
type: Class

Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models
type: Article
volume: 67
related by: authorship_71189
related by: authorship_71192
related by: authorship_71195
has publication venue: Veterinarni Medicina
accesstype: All Open Access, Gold
type: Document
most specific type: Review
abstract: The objective of this review is to ascertain the advantages and disadvantages of several treatments and therapeutic protocols that have been used for the prevention and treatment of perinatal asphyxia in human neonates and in different animal models. Perinatal asphyxia is one of the main causes of mortality worldwide and is an important factor in triggering physio-metabolic disorders that result in serious neurological consequences and learning disorders not only in human foetuses and neonates, but also in animals. In recent years, the search for new pharmacological protocols to prevent and reverse physio-metabolic disorders and brain damage derived from perinatal asphyxia has been and continues to be the subject of intense research. Currently, within these pharmacological protocols, therapeutic strategies have been evaluated that use respiratory and hormonal stimulants, as well as hypothermic therapies in combination with other putative neuroprotective agents. Similarly, energy supplements have been evaluated with the objective of preventing perinatal asphyxia and treating new-borns with this condition, and to decrease the incidence of neonatal and foetal deaths associated with it. However, despite these promising advances, this pathology has persisted, since the administration of these therapies in low doses may not exert a neuroprotective effect or, in high doses, can trigger adverse effects (such as reduced cardiac contractility, reduced cerebral blood flow, poor perfusion, sympathetic and neuroendocrine stimulation, and increased blood viscosity) in human foetuses and neonates as well as in different animal models (rats, piglets, sheep and rabbits). Therefore, it is important to determine the minimum effective dose with which these therapies exert a neuroprotective effect, as well as the mode of administration, the duration of therapy, etc. Therefore, until a powerful strategy is found to improve the consequences of suffocation, this topic will continue to be t…
freetext keyword: hypoxic-ischemic encephalopathy; neonatal mortality; perinatal asphyxia acetylcysteine; adenosine; allopurinol; caffeine; cocarboxylase; creatinine; docosahexaenoic acid; endothelial nitric oxide synthase; erythropoietin; glutathione; inducible nitric oxide synthase; interleukin 10; interleukin 4; interleukin 5; melatonin; nitric oxide; superoxide dismutase; animal model; asphyxia; brain blood flow; brain cortex; brain development; brain perfusion; human; hypercapnia; hypothermia; hypoxemia; hypoxia; hypoxic ischemic encephalopathy; lung dysplasia; muscle contractility; nervous system development; neuroprotection; newborn; newborn mortality; nonhuman; oxygen consumption; perinatal asphyxia; respiration depression; Review
type: Information Content Entity
crisid: 10558
type: Review
related by: authorship_71190
related by: authorship_71193
doi: 10.17221/43/2021-VETMED
issue: 6
most specific type: Document
type: Generically Dependent Continuant
type: Thing
e iscopus: 2-s2.0-85128740797
page end: 297
type: Continuant
related by: authorship_71191
related by: authorship_71194
chemicalscas: acetylcysteine, 616-91-1; adenosine, 58-61-7; allopurinol, 315-30-0; caffeine, 58-08-2; cocarboxylase, 154-87-0; creatinine, 19230-81-0, 60-27-5; docosahexaenoic acid, 25167-62-8, 32839-18-2; endothelial nitric oxide synthase, 503473-02-7; erythropoietin, 11096-26-7; glutathione, 70-18-8; inducible nitric oxide synthase, 501433-35-8; melatonin, 73-31-4; nitric oxide, 10102-43-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1
estado: published
page start: 271
origen: scopus
date time value: review date 10558
type: Entity

individual
rights: termsOfUse
date: 2026-08-26T04:03:58
publisher: vivo
type: Document
label: RDF description of Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models - http://orbis.uaslp.mx/vivo/individual/scopus10557

Article
type: Class

Information Content Entity
type: Class

Veterinarni Medicina
type: Thing
type: Generically Dependent Continuant
publication venue for: Treatments and therapeutic protocols for the recovery of an asphyxiated new-born: A review of pre-clinical and clinical studies in human neonates and in different animal models
type: Entity
type: Information Content Entity
type: Collection
type: Periodical
type: Journal
type: Continuant
type: Document