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A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity
page start: 1268
pmid: 34983345
type: Information Content Entity
estado: published
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page end: 1280
related by: authorship_69583
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most specific type: Document
has funding vehicle: Consejo Nacional de Ciencia y Tecnología, CONACYT: 712595, SEP-82585
chemicalscas: Antiviral Agents; Benzimidazoles; Metals
type: Article
has publication venue: Mini-Reviews in Medicinal Chemistry
abstract: The therapeutic potential of the benzimidazole nucleus has been recognized since 1944, and it is an important heterocycle system due to its presence in a wide range of bioactive compounds such as antiviral, anticancer, antibacterial, and so on, where optimization of substituents in this class of pharmacophore has resulted in many drugs. Its broad biological activity stems from physicochemical properties such as hydrogen bond donor-acceptor capability, π→π stacking interactions, coordination bonds with metals as ligands and hydrophobic interactions; properties that allow them to easily bind with a series of biomolecules, including enzymes and nucleic acids, causing a growing interest in these types of molecules. This review aims to present an overview to leading benzimidazole derivatives, as well as to show the importance of the nature and type of substituents at the N1, C2, and C5(6) positions when they are biologically evaluated, which can lead to obtaining potent drug candidate with a significant range of biological activities. © 2022 Bentham Science Publishers.
freetext keyword: Benzimidazole; Biological activity; Heterocycle; Medicinal chemistry; Structure-activity relationship antivirus agent; benzimidazole derivative; metal; chemistry; structure activity relation; Antiviral Agents; Benzimidazoles; Metals; Structure-Activity Relationship
issue: 9
e iscopus: 2-s2.0-85132453084
type: Generically Dependent Continuant
type: Document
date time value: article date 10100
most specific type: Article
doi: 10.2174/1389557522666220104150051
origen: scopus
crisid: 10100
volume: 22
related by: authorship_69584

RDF description of A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity - http://orbis.uaslp.mx/vivo/individual/scopus10099
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date: 2026-08-28T03:09:21
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Consejo Nacional de Ciencia y Tecnología, CONACYT: 712595, SEP-82585
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funding vehicle for: A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity

Mini-Reviews in Medicinal Chemistry
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publication venue for: A Panoramic Review of Benzimidazole Derivatives and their Potential Biological Activity
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