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RDF description of Regulatory T cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction - http://orbis.uaslp.mx/vivo/individual/d11513
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date: 2026-08-24T21:53:40
publisher: vivo
type: Document

Article
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Regulatory T cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction
type: Entity
type: Document
type: Continuant
has publication venue: Clinical and Experimental Immunology
artnum: uxae014
freetext keyword: regulatory T cell, CD69, acute myocardial infarction, inflammation
related by: authorship_73369
related by: authorship_73370
crisid: 11514
date time value: article date 11514
type: Generically Dependent Continuant
most specific type: Article
type: Article
abstract: A high percentage of patients with acute coronary syndrome develop heart failure due to the ischemic event. Regulatory T (Treg) cells are lymphocytes with suppressive capacity that control the immune response and include the conventional CD4 CD25hi Foxp3 cells and the CD4 CD25var CD69 LAP Foxp3- IL-10 cells. No human follow-up studies focus on Treg cells’ behavior after infarction and their possible relationship with ventricular function as a sign of post-ischemic cardiac remodeling. This study aimed to analyze, by flow cytometry, the circulating levels of CD69 regulatory T cells and CD4 CD25hi Foxp3 cells, its IL-10 production as well as their function in patients with acute myocardial infarction (AMI), and its possible relation with ventricular dysfunction. We found a significant difference in the percentage of CD4 CD25hi Foxp3 cells and IL-10 MFI in patients with AMI at 72 hours compared with the healthy control group, and the levels of these cells were reduced six months post-AMI. Regarding the suppressive function of CD4 CD25 regulatory cells, they were dysfunctional at three- and six-months post-AMI. The frequency of CD69 Treg cells was similar between patients with AMI at 72 hours post-infarction and the control groups. Moreover, the frequency of CD69 Treg cells at three months and six months post-ischemic event did not vary over time. Treg cells play a role in regulating inflammation after an acute myocardial infarction, and its function may be compromised in this pathology. This work is the first report to evaluate CD69 Foxp3- Treg cells in AMI patients
related by: authorship_73368
type: Thing
doi: 10.1093/cei/uxae014
most specific type: Document
type: Information Content Entity
estado: published
related by: authorship_73367

Information Content Entity
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Clinical and Experimental Immunology
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type: Generically Dependent Continuant
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publication venue for: Regulatory T cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction
type: Periodical
type: Continuant
type: Document