Document
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Consejo Nacional de Ciencia y Tecnología (CONACyT) B-S-40505; International Atomic Energy Agency IAEA RLA 1018
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type: BFO_0000020
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type: Grant
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funding vehicle for: Radiosterilized Pig Skin, Silver Nanoparticles and Skin Cells as an Integral Dressing Treatment for Burns: Development, Pre-Clinical and Clinical Pilot Study

Continuant
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Entity
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Generically Dependent Continuant
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individual
rights: termsOfUse
date: 2026-08-27T05:31:15
publisher: vivo
type: Document
label: RDF description of Radiosterilized Pig Skin, Silver Nanoparticles and Skin Cells as an Integral Dressing Treatment for Burns: Development, Pre-Clinical and Clinical Pilot Study - http://orbis.uaslp.mx/vivo/individual/d11500

Article
type: Class

Radiosterilized Pig Skin, Silver Nanoparticles and Skin Cells as an Integral Dressing Treatment for Burns: Development, Pre-Clinical and Clinical Pilot Study
crisid: 11501
issue: 8
related by: authorship_73330
type: Generically Dependent Continuant
freetext keyword: Burns, Fibroblasts, Keratinocytes, Pre-clinical and clinical pilot study, Radiosterilized pig skin, Silver nanoparticles
type: Document
doi: 10.3390/pharmaceutics15082105
most specific type: Article
related by: authorship_73338
type: Article
related by: authorship_73334
related by: authorship_73333
type: Information Content Entity
type: Thing
type: Entity
related by: authorship_73337
date time value: article date 11501
pmid: 37631319
volume: 15
accesstype: Open Access
has publication venue: Pharmaceutics
related by: authorship_73332
related by: authorship_73329
has funding vehicle: Consejo Nacional de Ciencia y Tecnología (CONACyT) B-S-40505; International Atomic Energy Agency IAEA RLA 1018
estado: published
related by: authorship_73331
type: Continuant
abstract: Radiosterilized pig skin (RPS) has been used as a dressing for burns since the 1980s. Its similarity to human skin in terms of the extracellular matrix (ECM) allows the attachment of mesenchymal stem cells, making it ideal as a scaffold to create cellularized constructs. The use of silver nanoparticles (AgNPs) has been proven to be an appropriate alternative to the use of antibiotics and a potential solution against multidrug-resistant bacteria. RPS can be impregnated with AgNPs to develop nanomaterials capable of preventing wound infections. The main goal of this study was to assess the use of RPS as a scaffold for autologous fibroblasts (Fb), keratinocytes (Kc), and mesenchymal stem cells (MSC) in the treatment of second-degree burns (SDB). Additionally, independent RPS samples were impregnated with AgNPs to enhance their properties and further develop an antibacterial dressing that was initially tested using a burn mouse model. This protocol was approved by the Research and Ethics Committee of the INRLGII (INR 20/19 AC). Transmission electron microscopy (TEM) and dynamic light scattering (DLS) analysis of the synthesized AgNPs showed an average size of 10 nm and rounded morphology. Minimum inhibitory concentrations (MIC) and Kirby–Bauer assays indicated that AgNPs (in solution at a concentration of 125 ppm) exhibit antimicrobial activity against the planktonic form of S. aureus isolated from burned patients; moreover, a log reduction of 1.74 ± 0.24 was achieved against biofilm formation. The nanomaterial developed with RPS impregnated with AgNPs solution at 125 ppm (RPS-AgNPs125) facilitated wound healing in a burn mouse model and enhanced extracellular matrix (ECM) deposition, as analyzed by Masson’s staining in histological samples. No silver was detected by energy-dispersive X-ray spectroscopy (EDS) in the skin, and neither by Inductively Coupled Plasma Mass Spectrometry (ICP-MS) in different organs of the mouse burn model. Calcein/ethidium homodimer (EthD-1),…
related by: authorship_73336
most specific type: Document
related by: authorship_73339
related by: authorship_73335
artnum: 2105

Pharmaceutics
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publication venue for: Radiosterilized Pig Skin, Silver Nanoparticles and Skin Cells as an Integral Dressing Treatment for Burns: Development, Pre-Clinical and Clinical Pilot Study
type: Journal
type: Generically Dependent Continuant
type: Document
type: Continuant
type: Thing
type: Information Content Entity

Information Content Entity
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