Document
type: Class

Evaluation of the Local Synergistic Effect of a Dexketoprofen and Chlorhexidine Combination in the Formalin Test
estado: published
date time value: article date 11187
accesstype: Open Access
type: Thing
type: Continuant
related by: authorship_72527
volume: 42
related by: authorship_72529
most specific type: Article
related by: authorship_72526
abstract: Objective: Evidence supports the local application of non-steroidal antiinflammatory drugs such as dexketoprofen trometamol (DXT) for pain management, but little is known about the potential antinociceptive effect of chlorhexidine gluconate (CHX) and its possible synergistic effect when combined with DXT. The aim of this study was to evaluate the local effect of a DXT–CHX combination using isobolographic analysis in a formalin pain model in rats. Materials and Methods: Briefly, 60 female Wistar rats were used for the formalin test. Individual dose-effect curves were obtained using linear regression. For each drug, the percentage of antinociception and median effective dose (ED50; 50%25 of antinociception) were calculated, and drug combinations were prepared using the ED50s for DXT (phase 2) and CHX (phase 1). The ED50 of the DXT–CHX combination was determined, and an isobolographic analysis was performed for both phases. Results: The ED50 of local DXT was 5.3867 mg/mL in phase 2 and for CHX was 3.9233 mg/mL in phase 1. When the combination was evaluated, phase 1 showed an interaction index (II) of less than 1, indicating synergism but without statistical significance. For phase 2, the II was 0.3112, with a reduction of 68.88%25 in the amounts of both drugs to obtain the ED50; this interaction was statistically significant (P <.05). Conclusion: DXT and CHX had a local antinociceptive effect and exhibited synergistic behavior when combined in phase 2 of the formalin model. © 2023, University of Puerto Rico. All rights reserved.
related by: authorship_72528
type: Document
freetext keyword: Antinociception, Formalin test, Synergism, Dexketoprofen trometamol, Chlorhexidine gluconate
most specific type: Document
type: Generically Dependent Continuant
issue: 1
has funding vehicle: CONACYT [599447/326741]; UASLP grant [C18-FAI-05-50.50]
pmid: 36941097
has publication venue: Puerto Rico Health Sciences Journal
related by: authorship_72525
type: Entity
crisid: 11187
type: Information Content Entity
type: Article
page end: 42
page start: 35

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RDF description of Evaluation of the Local Synergistic Effect of a Dexketoprofen and Chlorhexidine Combination in the Formalin Test - http://orbis.uaslp.mx/vivo/individual/d11186
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date: 2026-08-25T21:07:31
publisher: vivo
type: Document

Article
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Puerto Rico Health Sciences Journal
type: Periodical
type: Information Content Entity
type: Continuant
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type: Entity
type: Journal
publication venue for: Evaluation of the Local Synergistic Effect of a Dexketoprofen and Chlorhexidine Combination in the Formalin Test
type: Document
type: Thing
type: Generically Dependent Continuant

CONACYT [599447/326741]; UASLP grant [C18-FAI-05-50.50]
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type: BFO_0000020
type: Entity
type: Thing
type: Grant
type: Continuant
funding vehicle for: Evaluation of the Local Synergistic Effect of a Dexketoprofen and Chlorhexidine Combination in the Formalin Test