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Continuant
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Effect of thiamine pyrophosphate on the characteristics of farrowing and piglet vitality
most specific type: Document
has funding vehicle: Mexico\'s Consejo Nacional de Ciencia y Tecnologia (CONACYT) [635369]
pmid: 36758457
type: Entity
type: Information Content Entity
crisid: 11146
type: Document
page end: 59
freetext keyword: Asphyxia, Piglets, Thiamine pyrophosphate, Physiological
type: Thing
has publication venue: Theriogenology
most specific type: Article
volume: 200
related by: authorship_72420
estado: published
doi: 10.1016/j.theriogenology.2023.01.029
related by: authorship_72421
related by: authorship_72419
abstract: Asphyxia is considered the main non-infectious cause of prepartum mortality in swine, as well as an important factor that negatively affects neonatal vitality and can trigger physiological and metabolic disorders. Hence, the search for pharmacological protocols to reduce the harmful effects of asphyxia is a key area of research. Recent observations show that administering thiamine pyrophosphate (TPP) prior to a hypoxic event in certain species (rabbits, rats) has a neuroprotector effect that preserves energy metabolism under hypoxic conditions. Given this, the objective of this study was to evaluate a prophylactic protocol in high- and low-vitality neonate piglets based on TPP\%27s effect on physiological and metabolic responses, body temperature, and weight. A total of 149 piglets born from 15 multiparous sows were used. The dams were randomly divided into two groups: control (NaCl 0.9%25) and TPP (25 ml of TTP) administered 24 and 12 h before the expected farrowing date. The following reproductive variables of the sows were recorded: duration of farrowing, total number of piglets born per litter, number of liveborn piglets per litter, number of stillbirths and mummified fetuses at birth, and number of live piglets at weaning. In addition, the expulsion interval and vitality of all neonates were evaluated, body temperatures were recorded at ten intervals, and physiological profiles (blood gases, electrolytes, glucose) were registered for each neonate. Results show that the TPP-treated sows had shorter farrowing duration (P 1/4 0.0060) and higher percentage of high-vitality neonates (60%25). Moreover, their offspring exhibited greater vitality, fewer imbalances in their physiological and metabolic profiles, and greater weight gain at weaning (P < 0.0001). Findings suggest that administering TPP exerts a protective effect when hypoxic events occur, though this differs from results obtained with rat pups, where applying TPP after such events did not provide protection…
date time value: article date 11146
type: Article
related by: authorship_72422
type: Generically Dependent Continuant
type: Continuant
page start: 49
related by: authorship_72423

Generically Dependent Continuant
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RDF description of Effect of thiamine pyrophosphate on the characteristics of farrowing and piglet vitality - http://orbis.uaslp.mx/vivo/individual/d11145
rights: termsOfUse
date: 2026-08-25T22:11:59
publisher: vivo
type: Document

Article
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Information Content Entity
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Theriogenology
type: Periodical
publication venue for: Effect of thiamine pyrophosphate on the characteristics of farrowing and piglet vitality
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type: Continuant
type: Journal
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type: Thing
type: Information Content Entity
type: Document
type: Generically Dependent Continuant

Mexico\'s Consejo Nacional de Ciencia y Tecnologia (CONACYT) [635369]
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type: BFO_0000020
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type: Grant
type: Continuant
funding vehicle for: Effect of thiamine pyrophosphate on the characteristics of farrowing and piglet vitality