Anti-hiv and anti-candidal effects of methanolic extract from heteropterys brachiata
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Nowadays, the HIV pandemic is far from controlled. HIV%2b/AIDS patients show a serious risk of developing resistance to HIV antiretroviral drugs and to be orally colonized by albicans and non-albicans Candida strains resistant to antifungals. As a consequence, new drugs that possess anti-candidal and anti-HIV effects would represent an alternative in the comprehensive treatment of HIV%2b/AIDS patients. The present study evaluates the possible anti-HIV and anti-Candida effects of a methanolic extract from Heteropterys brachiata (Hb MeOH), an American tropical plant. The anti-HIV effect of Hb MeOH was tested using a non-radioactive colorimetric method (Lenti RT® Activity Assay; Cavidi Tech) that uses reverse transcriptase of HIV-1 enzyme as enzymatic target. The anti-candidal effect of HbMeOH extract was evaluated by following a standardized test protocol of microdilution for yeast using the Candida albicans strain ATCC® 90028. The Hb MeOH at 1 mg/mL concentration shows 38.5%25 RT-HIV inhibition, while Hb MeOH at 10 mg/mL concentration produced 98%25 C. albicans growth inhibition. Our findings show that the Hb MeOH possesses a strong anti-candidal activity and moderate anti-HIV effect and suggests that the plant extract could be considered as a potential candidate for HIV/AIDS treatment. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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AIDS; Antifungal treatment; Antiretroviral treatment; Candidiasis; Heteropterys; HIV; Malpighiaceae anti human immunodeficiency virus agent; Candida antigen; chlorogenic acid; fluconazole; methanol; nevirapine; plant extract; antifungal agent; plant extract; acquired immune deficiency syndrome; epidemic; health risk; human immunodeficiency virus; plant extract; public health; sexually transmitted disease; acquired immune deficiency syndrome; antifungal therapy; Article; Candida albicans; candidiasis; colorimetry; controlled study; enzyme activity; growth inhibition; heteropterys brachiata; Human immunodeficiency virus 1; Human immunodeficiency virus infection; Malpighiaceae; nonhuman; Candida; human; microbial sensitivity test; Candida; Candida albicans; Heteropterys; Malpighiaceae; Antifungal Agents; Candida; Candida albicans; Humans; Methanol; Microbial Sensitivity Tests; Plant Extracts
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