Platelets immune response against Mycobacterium tuberculosis infection
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Tuberculosis (TB) is the first cause of death by a single infectious agent. Previous reports have highlighted the presence of platelets within Tb granulomas, albeit the immune-associated platelet response to Mycobacterium tuberculosis (Mtb) has not been deeply studied. Our results showed that platelets are recruited into the granuloma in the late stages of tuberculosis. Furthermore, electron-microscopy studies showed that platelets can internalize Mtb and produce host defense peptides (HDPs), such as RNase 7, HBD2 and hPF-4 that bind to the internalized Mtb. Mtb-infected platelets exhibited higher transcription and secretion of IL-1β and TNF-α, whereas IL-10 and IL-6 protein levels decreased. These results suggest that platelets participate in the immune response against Mtb through HDPs and cytokines production. © 2021 Elsevier Ltd
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Host defense peptides; Immune response; Platelets; Tuberculosis beta defensin 2; fibrinogen receptor; interleukin 10; interleukin 1beta; interleukin 6; ribonuclease; ribonuclease 7; thrombocyte factor 4; tumor necrosis factor; unclassified drug; cytokine; animal cell; animal experiment; animal tissue; Article; Bagg albino mouse; controlled study; cytokine production; cytokine release; electron microscopy; immune response; immunohistochemistry; lymphocyte; macrophage; male; mouse; Mycobacterium tuberculosis; nonhuman; priority journal; thrombocyte; transmission electron microscopy; tuberculosis; granuloma; human; immunity; Mycobacterium tuberculosis; thrombocyte; Blood Platelets; Cytokines; Granuloma; Humans; Immunity; Mycobacterium tuberculosis; Tuberculosis
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