Transgenic plants: A 5-year update on oral antipathogen vaccine development

The progressive interest in transgenic plants as advantageous platforms for the production and oral delivery of vaccines has led to extensive research and improvements in this technology over recent years. In this paper, the authors examine the most significant advances in this area, including novel approaches for higher yields and better containment, and the continued evaluation of new vaccine prototypes against several infectious diseases. The use of plants to deliver vaccine candidates against viruses, bacteria, and eukaryotic parasites within the last 5 years is discussed, focusing on innovative expression strategies and the immunogenic potential of new vaccines. A brief section on the state of the art in mucosal immunity is also included. © 2014 Informa UK Ltd.

Delivery system; Marker-free system; Oral immunization; Transgenic plant; Transplastomic technology; Vaccine; Viral expression vector elastin like polypeptide; hybrid protein; hydrophobin; hydrophobin I; polypeptide; recombinant protein; unclassified drug; vaccine; virus vector; edible vaccine; antigen expression; bacterium; biosafety; DNA virus; drug delivery system; human; immunogenicity; infection; infection prevention; marker gene; mucosal immunity; nonhuman; oral vaccination; parasite; phase 1 clinical trial (topic); Review; RNA virus; transgenic plant; transgenics; transplastomics; vaccination; vaccine production; virus; virus expression; virus like agent; drug development; genetics; immunology; oral drug administration; procedures; trends; vaccination; Administration, Oral; Drug Discovery; Immunity, Mucosal; Plants, Genetically Modified; Vaccination; Vaccines, Edible

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