Interaction of intrarenal adenosine and angiotensin II in kidney vascular resistance
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The ADO-metabolizing enzymes have become important regulators of the effects of ADO on the tone of the afferent and efferent arterioles. As Angll is able to increase de-novo renal ADO content through decrease of ADO-metabolizing enzymes, accumulation of ADO induces downregulation of ADO A2 receptor population without modifying ADO A1 receptor, thereby enhancing the constrictive effects of Angll in the renal vasculature. © 2009 Wolters Kluwer Health.
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Adenosine; Adenosine deaminase; Adenosine receptors; Angiotensin II; Angiotensin II AT1 receptors; Ecto-5'-nucleotidase adenosine; adenosine A1 receptor; adenosine A2 receptor; adenosine triphosphate; angiotensin II; ecto 5' nucleotidase; messenger RNA; voltage gated calcium channel; arteriole; blood vessel tone; calcium binding; calcium mobilization; calcium signaling; calcium transport; down regulation; enzyme activity; enzyme degradation; enzyme regulation; glomerulus filtration rate; high sodium intake; human; kidney vascular resistance; nitration; nitrosylation; nonhuman; Northern blotting; priority journal; protein dephosphorylation; protein expression; protein protein interaction; renin release; reverse transcription polymerase chain reaction; review; vascular resistance; Western blotting; Adenosine; Angiotensin II; Animals; Humans; Kidney; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide; Renal Circulation; Sodium Chloride; Vascular Resistance
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