abstract

• Al-doped HfO2 nanoparticles were prepared at room-temperature using a novel one-step, straightforward, high-yield, efficient and green process. It includes a mechanically activated metathesis reaction that promotes the direct crystallization of cubic HfO2 (c-HfO2) in milling. Al-cation was used as dopant, achieving c-HfO2 stabilization at low content (5%25 mol). The c-HfO2 is stable up to 380 °C without exhibiting transformation from the cubic to monoclinic polymorph. The c-HfO2 showed spherical-like morphology with diameter below 7 nm. Human Prostate Epithelial Cells (HPrEC) were used to evaluate nanoparticles toxicity. Cells viability and survival were determined performing MTS and colony formation assays. Nanoparticles were found harmless for cells metabolic activity at concentrations up to 1000 μg/mL. A decrease of ~30%25 on HPrEC plating efficiency was observed at the highest concentration. © 2020 Elsevier B.V.

authors

• Castillo-Ramírez J.A.
• Escudero Lourdes Claudia
• Garcia-Cerda L.A.
• Mendoza-Mendoza E.
• Salado-Leza D.

publication date

• 2020-01-01

funding provided via

• Consejo Nacional de Ciencia y Tecnología, CONACYT: Project/CB-2016-285350  Grant
• Universidad Autónoma de San Luis Potosí, UASLP: Project/C19-FAI-05-87-87  Grant

published in

• Materials Letters  Journal

keywords

• Al-dopant; HfO2 nanoparticles; Milling; Prostate cells; Synthesis; Toxicity Aluminum compounds; Cells; Cytology; Nanoparticles; Synthesis (chemical); Toxicity; Urology; Cells viabilities; Colony formation; Epithelial cells; Metabolic activity; Metathesis reactions; Monoclinic polymorphs; Plating efficiency; Room temperature synthesis; Hafnium oxides

Digital Object Identifier (DOI)

• 10.1016/j.matlet.2020.128048

start page

end page

volume

• 274