Influence of diameter of fiber membrane scaffolds on the biocompatibility of hpdl mesenchymal stromal cells
Article
-
- Overview
-
- Research
-
- Identity
-
- Additional Document Info
-
- View All
-
Overview
abstract
-
This study evaluated the influence in the biocompatibility of human periodontal ligament (hPDL) mesenchymal stromal cell onto poly lactic-acid (PLA) films and PLA fiber membrane. Fiber scaffold was prepared via air jet spinning (AJS) from PLA solutions (6, 7, and 10%25) and analyzed using SEM, AFM and FTIR. Biocompatibility was evaluated by adhesion, proliferation and cell-material interaction. PLA film exhibited a smooth and homogenously surface topography in comparison with random orientation of PLA fiber with roughness structure where diameter size depends on PLA solution. Moreover, cell adhesion; proliferation and cell-material interaction has the best respond on random orientation nanofiber of 10, followed by 7, and 6%25 of PLA in comparison with PLA films. It could be concluded that AJS is an attractive alternative technique for manufacture fiber scaffolds with a tunable random orientation geometry of fibers that allow to produce interconnected porous formed by nanometric fiber diameter structures that could be a potential scaffold for periodontal tissue engineering applications. © 2018, Japanese Society for Dental Materials and Devices. All rights reserved.
publication date
funding provided via
Research
keywords
-
Biocompatibility; Biomaterials; Cell viability; Nanofibers; Periodontal ligament Biocompatibility; Biomaterials; Cell adhesion; Cells; Fibers; Lactic acid; Nanofibers; Spinning (fibers); Surface topography; Topography; Cell viability; Cell-material interaction; Human periodontal ligament; Mesenchymal stromal cells; Periodontal ligament; Periodontal tissue; Random orientations; Roughness structures; Scaffolds (biology); biomaterial; nanofiber; polyester; polylactide; adolescent; adult; atomic force microscopy; cell adhesion; cell proliferation; cell survival; chemistry; cytology; human; materials testing; mesenchymal stem cell; periodontal ligament; premolar tooth; procedures; scanning electron microscopy; surface property; tissue engineering; tissue scaffold; Adolescent; Adult; Bicuspid; Biocompatible Materials; Cell Adhesion; Cell Proliferation; Cell Survival; Humans; Materials Testing; Mesenchymal Stem Cells; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Nanofibers; Periodontal Ligament; Polyesters; Surface Properties; Tissue Engineering; Tissue Scaffolds
Identity
Digital Object Identifier (DOI)
PubMed ID
Additional Document Info
start page
end page
volume
issue