Incidence of Clostridium difficile infection and antibiotics use in a third-level hospital [Incidencia de infección por Clostridium difficile asociada a antibióticos en un hospital de tercer nivel]

Clostridium difficile (cd) is a Gram-positive, spore-forming, anaerobic, toxin-producing bacterium (a and b). Clostridium difficile infection (cdi) is one of the health care-associated infections (hcai). People with weakened conditions have a higher risk of cdi, especially when they are in intensive care units for prolonged periods, keeping them exposed to circulating spores. Other risk factors are the indiscriminate use of antibiotics: mainly metronidazole and vancomycin. objective. to determine the prevalence of Clostridium difficile infections in patients treated at a tertiary level hospital: Central Hospital Dr. Ignacio Morones Prieto, San Luis Potosí, during 2015, the main hospital areas affected and their possible relationship with the use of antibiotics were determined. results. 44%25 of toxin tests were positive, of which 54.4%25 were positive for both toxins. The areas with the highest cdi incidence were Hospitalization (35%25), Surgery (27%25) and Intensive care units (22%25), and the areas with greater use of metronidazole: Surgery and icu, while for vancomycin, Hospitalization and Surgery. conclusions. the results suggest that there may be a relationship between intrahospital treatment with antibiotics and the development of cdi, due to the fact that antibiotics alter intestinal biota. © 2017 Elsevier Doyma. All rights reserved.

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