Obesity is associated with the Arg389Gly ADRB1 but not with the Trp64Arg ADRB3 polymorphism in children from San Luis Potosí and León, México Article uri icon


  • This research was designed to analyze the possible associations of Arg389Gly ADRB1 and Trp64Arg ADRB3 polymorphisms in children with obesity. A cross-sectional study included 1,046 school-age Mexican participants (6- 12 years old) from the cities of San Luis Potosí and León. Children were classified as non-obese or obese according to their body mass index (BMI) percentile; obese children had a BMI ≥ 95th percentile for sex and age. Biochemical data were collected. Polymorphisms were detected using TaqMan qPCR assay. A logistic regression analysis was used to calculate the risk of obesity based on genotypes. Differences were found between groups where obese children had a significant increase in systolic and diastolic blood pressure, fasting plasma glucose, insulin, HOMAIR, LDL-cholesterol, triglycerides, and lower HDL-cholesterol compared with the normal weight group (P < 0.05). The distribution of allele frequency in the population was Arg = 87.4 and Gly = 12.6 (Hardy Weinberg equilibrium χ2 = 3.16, P = 0.07 ); Trp = 81.5 and Arg = 18.5 (Hardy Weinberg equilibrium χ2 = 2.2, P = 0.14 ) for ADRB1 and ADRB3, respectively. Even though no different frequencies of Arg389Gly polymorphism between groups were found (P = 0.08), children carriers of one Gly389 ADRB1 allele had a risk for obesity of OR = 1.40 (95%25CI, 1.03-1.90, P = 0.03) after adjustment for age and gender. No other association was found for Trp64Arg ADRB3 polymorphism. Only the Arg389Gly ADRB1 polymorphism was associated with risk for obesity in Mexican children. © 2017 by the Journal of Biomedical Research. All rights reserved.

publication date

  • 2017-01-01