Pharmacokinetics of oral ranitidine in Mexicans Article

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Overview

abstract

• The pharmacokinetics of oral ranitidine were studied in 24 Mexican male healthy volunteers. Subjects received a tablet containing 150 mg of ranitidine (Azantac®, Glaxo de Mexico, Mexico City) after an overnight fast and blood samples were drawn at several times for a period of 24 h. Ranitidine concentration in plasma was measured by high performance liquid chromatography and pharmacokinetic parameters were determined by non-compartmental analysis. Ranitidine plasma concentration increased with time, reaching a maximum of (mean ± SEM) 484 ± 34 ng/ml in 2.7 ± 0.2 h. Plasma levels then decayed with a terminal half-life of 4.8 ± 0.3 h. The area under the plasma concentration against time curve was 2440 ± 126 ng.h/ml. Oral ranitidine pharmacokinetic parameters in Mexicans appeared to be similar to those previously reported for Caucasians.

authors

• Castañeda-Hernández G.
• Flores-Murrieta F.J.
• Granados-Soto V.
• Herrera J.E.
• Herrera-Abarca A.
• Hong E.
• Pérez-Urizar J.

publication date

• 1996-01-01

published in

• Archives of Medical Research  Journal

Research

keywords

• Mexicans; Pharmacokinetics; Ranitidine histamine h2 receptor antagonist; ranitidine; adult; area under the curve; article; drug blood level; drug half life; high performance liquid chromatography; human; human experiment; male; oral drug administration; Administration, Oral; Adult; Chromatography, High Pressure Liquid; Ethnic Groups; Half-Life; Humans; Male; Mexico; Ranitidine; Tablets

Identity

PubMed ID

• 8854394

Additional Document Info

start page

• 349

end page

• 352

volume

• 27

issue

• 3