abstract

• Antimicrobial agents have been developed for drug-resistance infections, which have been rapidly increasing; however, the control of involved microorganisms is still a challenge. In this work, SNP with bovine serum albumin (BSA) and chitosan (CS) coatings were prepared with an aqueous reduction method, characterized using dispersion light scattering, transmission electron microscopy, and thermal analysis. Antibacterial activity was tested on seven oral and nonoral bacteria by microdilution test and scanning electron microscopy. Six different sizes and shapes of coated SNP were prepared and used. Characterization revealed narrow size and good distribution of particles, spherical and pseudospherical shapes, and the presence of coatings on the SNP surfaces. All samples showed antimicrobial activity, although smaller sizes and CS samples had the best inhibition effects. The highest microbial resistance was shown by Gram-positive bacteria. Although coated SNP action depends on particular bacterium, BSA and CS coated SNP could be used for drug-resistance infections. © 2015 León Francisco Espinosa-Cristóbal et al.

authors

• Espinosa-Cristóbal L.F.
• Lara R.H.
• Loyola-Rodríguez J.P.
• Martínez Castañón Gabriel Alejandro
• Niño Martínez Nereyda
• Reyes-López S.Y.
• Ruiz Facundo
• Zavala Alonso Norma Verónica

publication date

• 2015-01-01

keywords

• Antimicrobial agents; Body fluids; Chitin; Chitosan; Coatings; Drug therapy; Electron microscopy; High resolution transmission electron microscopy; Light scattering; Light transmission; Mammals; Microorganisms; Scanning electron microscopy; Silver; Surface plasmon resonance; Thermoanalysis; Transmission electron microscopy; Anti-bacterial activity; Anti-microbial activity; Aqueous reduction methods; Bovine serum albumins; Distribution of particles; Gram-positive bacterium; Microbial resistance; Silver nanoparticles; Bacteria

Digital Object Identifier (DOI)

• 10.1155/2015/420853

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volume

• 2015