Characterization of antidiabetic and antihypertensive properties of canary seed (Phalaris canariensis L.) peptides
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Canary grass is used as traditional food for diabetes and hypertension treatment. The aim of this work is to characterize the biological activity of encrypted peptides released after gastrointestinal digestion of canary seed proteins. Canary peptides showed 43.5%25 inhibition of dipeptidyl peptidase IV (DPPIV) and 73.5%25 inhibition of angiotensin-converting enzyme (ACE) activity. An isolated perfused rat heart system was used to evaluate the canary seed vasoactive effect. Nitric oxide (NO), a major vasodilator agent, was evaluated in the venous effluent from isolated perfused rat heart. Canary seed peptides (1 μg/mL) were able to induce the production of NO (12.24 μM) in amounts similar to those induced by captopril (CPT) and bradykinin (BK). These results show that encrypted peptides in canary seed have inhibitory activity against DPPIV and ACE, enzymes that are targets for diabetes and hypertension treatments. © 2013 American Chemical Society.
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angiotensin-converting enzyme; canary seed; dipeptidyl peptidase IV; encrypted peptides; nitric oxide Angiotensin-converting enzyme; Anti diabetics; Antihypertensive properties; Dipeptidyl peptidase iv; Gastrointestinal digestion; Inhibitory activity; Seed protein; Traditional food; Angiotensin-converting enzyme; Anti diabetics; Antihypertensive properties; Dipeptidyl peptidase iv; Gastrointestinal digestion; Inhibitory activity; Seed protein; Traditional food; Bioactivity; Cryptography; Enzyme activity; Nitric oxide; Peptides; Bioactivity; Cryptography; Enzyme activity; Enzymes; Nitric oxide; Peptides; Proteins; Rats; Enzyme inhibition; Enzyme inhibition; Phalaris aquatica; Phalaris canariensis; Rattus; antidiabetic agent; antihypertensive agent; bradykinin; captopril; dipeptidyl carboxypeptidase; dipeptidyl carboxypeptidase inhibitor; nitric oxide; peptide; seed storage protein; vasodilator agent; animal; biosynthesis; chemistry; coronary blood vessel; digestion; drug effects; heart muscle; isolation and purification; male; metabolism; Phalaris; plant seed; rat; vasodilatation; Wistar rat; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Bradykinin; Captopril; Coronary Vessels; Digestion; Hypoglycemic Agents; Male; Myocardium; Nitric Oxide; Peptides; Peptidyl-Dipeptidase A; Phalaris; Rats; Rats, Wistar; Seed Storage Proteins; Seeds; Vasodilation; Vasodilator Agents
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