Decreased pre-surgical CD34 /CD144 cell number in patients undergoing coronary artery bypass grafting compared to coronary artery disease-free valvular patients
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Background: Cardiovascular disease has been linked to endothelial progenitor cell (EPC) depletion and functional impairment in atherosclerosis and aortic stenosis. EPCs may play a pivotal role in vascular grafting. However, the EPC depletion in coronary artery bypass grafting (CABG) patients has not been compared to coronary artery disease-free valvular replacement patients with aortic stenosis.Methods: We aimed to assess the basal number of CD34 /KDR and CD34 /CD144 cells in CABG patients, compared to aortic stenosis valvular replacement patients. 100 patients (51 CABG and 49 valvular surgery ones) were included in the present study. All CABG or valvular patients had angiographic demonstration of the presence or the absence of coronary artery disease, respectively. Numbers of CD34 /KDR and CD34 /CD144 were assessed by flow cytometry of pre-surgical blood samples.Results: We found a lower number of CD34 /CD144 cells in CABG patients compared to valvular patients (0.21 ± 0.03%25 vs. 0.47 ± 0.08%25), and this difference remained statistically significant after the P was adjusted for multiple comparisons (P = 0.01428). Both groups had more EPCs than healthy controls.Conclusions: Pre-surgical CD34 /CD144 numbers are decreased in CABG patients, compared to valvular patients with absence of coronary disease. © 2012 Redondo et al; licensee BioMed Central Ltd.
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Background: Cardiovascular disease has been linked to endothelial progenitor cell (EPC) depletion and functional impairment in atherosclerosis and aortic stenosis. EPCs may play a pivotal role in vascular grafting. However, the EPC depletion in coronary artery bypass grafting (CABG) patients has not been compared to coronary artery disease-free valvular replacement patients with aortic stenosis.Methods: We aimed to assess the basal number of CD34 %2b/KDR %2band CD34 %2b/CD144 %2bcells in CABG patients, compared to aortic stenosis valvular replacement patients. 100 patients (51 CABG and 49 valvular surgery ones) were included in the present study. All CABG or valvular patients had angiographic demonstration of the presence or the absence of coronary artery disease, respectively. Numbers of CD34 %2b/KDR %2band CD34 %2b/CD144 %2bwere assessed by flow cytometry of pre-surgical blood samples.Results: We found a lower number of CD34 %2b/CD144 %2bcells in CABG patients compared to valvular patients (0.21 ± 0.03%25 vs. 0.47 ± 0.08%25), and this difference remained statistically significant after the P was adjusted for multiple comparisons (P = 0.01428). Both groups had more EPCs than healthy controls.Conclusions: Pre-surgical CD34 %2b/CD144 %2bnumbers are decreased in CABG patients, compared to valvular patients with absence of coronary disease. © 2012 Redondo et al; licensee BioMed Central Ltd.
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Cardiac surgery; Coronary artery disease; Endothelial progenitor cells cadherin; CD34 antigen; leukocyte antigen; vascular endothelial cadherin; aged; angiocardiography; aorta valve stenosis; article; blood; cell count; comparative study; coronary artery bypass graft; coronary artery disease; coronary blood vessel; female; flow cytometry; heart valve replacement; human; immunology; male; middle aged; pathology; preoperative period; vascular endothelium; Aged; Antigens, CD; Antigens, CD34; Aortic Valve Stenosis; Cadherins; Cell Count; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Flow Cytometry; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Preoperative Period
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