Preliminary study of the inflammatory response to subcutaneous implantation of three root canal sealers
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Aim To evaluate the kinetics of the inflammatory tissue response to three root canal sealers using a physicochemical method for quantification of the enhanced vascular permeability and histopathological analysis. Methodology Twenty-eight male Wistar rats randomly assigned to four groups according to the evaluation periods (1, 3, 7 and 14days) were used to assess the vascular permeability and histopathological reaction to RoekoSeal, AH Plus and Sealapex (new formulation) sealers, using saline and Chloropercha as negative and positive controls, respectively. Seven rats were sacrificed per period. The biocompatibility of the sealers was evaluated spectrophotometrically and histopathologically. Results At day 14, Sealapex produced significantly more inflammatory exudate than AH Plus and RoekoSeal (P<0.05); however, there was no significant difference between AH Plus and RoekoSeal (P>0.05). Sealapex (new formulation) was the most irritating sealer, producing severe inflammation with the presence of multinucleated giant cells. RoekoSeal was the most biocompatible sealer, producing the least amount of inflammatory exudate. Conclusions RoekoSeal root canal sealer was biocompatible when implanted in connective tissue. © 2011 International Endodontic Journal.
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Plasma extravasation; Root canal sealers; Tissue compatibility AH Plus; balsam; calcium hydroxide; epoxy resin; gutta percha; roeko seal; root canal filling material; salicylic acid derivative; sealapex; tooth cement; zinc oxide; animal; article; capillary permeability; chemically induced disorder; comparative study; drug combination; drug effect; edema; foreign body reaction; immunology; implant; inflammation; kloroperka; male; nonparametric test; pilot study; rat; subcutaneous drug administration; time; Wistar rat; Animals; Balsams; Calcium Hydroxide; Capillary Permeability; Dental Cements; Drug Combinations; Edema; Epoxy Resins; Foreign-Body Reaction; Gutta-Percha; Implants, Experimental; Inflammation; Injections, Subcutaneous; Male; Pilot Projects; Rats; Rats, Wistar; Root Canal Filling Materials; Salicylates; Statistics, Nonparametric; Time Factors; Zinc Oxide
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