abstract

• The administration of methyl parathion as a single dose (12 mg / kg, p.o.) or chronic treatment (1 mg/kg/ day p.o. for 30 days) caused structural damage and loss of cells in the granular layer of cerebellum from adult Wistar male rats (weight 275g ± 25g), recorded by semiquantitative histological analysis. When we administered the standardized extract of Ginkgo biloba (69.8 μg/kg/ day i.p., every other day for 30 days) or N-acetylcysteine (150 mg/kg/day i.p., every other day for 30 days) as antioxidants, there was a significant neuroprotective effect (P <0.05) in the granular layer cells of rat cerebellum, only during chronic treatment. The results demonstrate the antioxidant neuroprotective effect that revert the damage caused by methyl parathion in the rat cerebellum.

authors

• Avelar-González F.J.
• Barrera A.L.G.
• Gutiérrez Cantú Francisco Javier
• Juárez F.J.
• Mariel Cárdenas Jairo
• Posadas Del Río F.A.
• Rodríguez-Vázquez M.L.
• Saldaña M.C.M.

publication date

• 2010-01-01

published in

• Revista Mexicana de Ciencias Farmaceuticas  Journal

keywords

• Cerebellum; Ginkgo biloba; Methyl parathion; Oxidative stress acetylcysteine; Ginkgo biloba extract; parathion methyl; animal experiment; antioxidant activity; article; cell loss; cell structure; cerebellum; drug activity; Ginkgo biloba; granule cell; histology; male; neuroprotection; nonhuman; rat; Wistar rat

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volume

• 41

issue

• 4