Paraoxonase gene mutations in amyotrophic lateral sclerosis Article

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Overview

abstract

• Three clustered, homologous paraoxonase genes (PON1, PON2, and PON3) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS). We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function. © 2010 American Neurological Association.

authors

• Bosco D.A.
• Brown Jr. R.H.
• Furlong C.E.
• Gellera C.
• Glass J.D.
• Keagle P.J.
• Landers J.E.
• Leclerc A.L.
• Mckenna-Yasek D.
• Ratti A.
• Rodríguez Leyva Ildefonso
• Sapp P.
• Silani V.
• Taroni F.
• Ticozzi N.
• Van Blitterswijk M.
• Wills A.-M.A.

publication date

• 2010-01-01

funding provided via

• National Institute of Environmental Health Sciences, NIEHS: R01ES009883  Grant
• National Institute of Neurological Disorders and Stroke, NINDS: R01NS050557  Grant

published in

• Annals of Neurology  Journal

Research

keywords

• aryldialkylphosphatase; aryldialkylphosphatase 1; aryldialkylphosphatase 2; aryldialkylphosphatase 3; genomic DNA; unclassified drug; amyotrophic lateral sclerosis; article; gene identification; gene mutation; genetic analysis; genetic variability; human; lipid oxidation; nonhuman; priority journal; Amino Acid Sequence; Amyotrophic Lateral Sclerosis; Aryldialkylphosphatase; DNA Mutational Analysis; Esterases; Family; Humans; Mutation; Sequence Homology, Amino Acid

Identity

Digital Object Identifier (DOI)

• 10.1002/ana.21993

PubMed ID

• 20582942

Additional Document Info

start page

• 102

end page

• 107

volume

• 68

issue

• 1