abstract
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Cadmium, an environmental and occupational health hazard, can substitute for calcium in the activation of calmodulin in several in vitro assays. It was shown that Cd2 can substitute for Ca2 in the induction of actin-based gelation in cytoplasmic extracts from rat liver; gelation induced by either Ca2 or Cd2 is inhibited by trifluoperazine, a well known calmodulin inhibitor; and in MDCK cells there is a Cd2 -induced redistribution of actin filaments with the loss of stress fibres and the appearance of actin bundles at the periphery of these cells. © 1989.
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Cadmium, an environmental and occupational health hazard, can substitute for calcium in the activation of calmodulin in several in vitro assays. It was shown that Cd2%2b can substitute for Ca2%2b in the induction of actin-based gelation in cytoplasmic extracts from rat liver; gelation induced by either Ca2%2b or Cd2%2b is inhibited by trifluoperazine, a well known calmodulin inhibitor; and in MDCK cells there is a Cd2%2b-induced redistribution of actin filaments with the loss of stress fibres and the appearance of actin bundles at the periphery of these cells. © 1989.
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