A defect in immunoregulatory synovial fluid T cells in Behcet's syndrome Article uri icon

abstract

  • Synovial fluid mononuclear cells from 5 patients with active Behcet%27s syndrome who were receiving no treatment were observed to have: decreased proportions of CD4 and CD8 cells, decreased proliferative responses of T cells in AMLR, poor capacity of non-T cells to stimulate in AMLR, decreased production of IL-2 upon PHA stimulation as compared both to their own peripheral blood mononuclear cells and to synovial fluid and peripheral blood mononuclear cells from 6 patients with RA and 6 patients with synovial effusions due to noninflammatory conditions. These findings provide further evidence of an immunoregulatory disturbance in Behcet%27s syndrome and indicate that synovial fluid, may be an important site where this derangement occurs in the active stage of the disease. © 1989 Springer-Verlag.
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publication date

  • 1989-01-01