Regulatory T-cell frequency and function in acute myocardial infarction patients and its correlation with ventricular dysfunction
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abstract
A high percentage of patients with acute coronary syndrome develop heart failure due to the ischemic event. Regulatory T (Treg) cells are lymphocytes with suppressive capacity that control the immune response and include the conventional CD4 CD25hi Foxp3 cells and the CD4 CD25var CD69 LAP Foxp3- IL-10 cells. No human follow-up studies focus on Treg cells%27 behavior after infarction and their possible relationship with ventricular function as a sign of postischemic cardiac remodeling. This study aimed to analyze, by flow cytometry, the circulating levels of CD69 Treg cells and CD4 CD25hi Foxp3 cells, their IL-10 production as well as their function in patients with acute myocardial infarction (AMI), and its possible relation with ventricular dysfunction. We found a significant difference in the percentage of CD4 CD25hi Foxp3 cells and IL-10 MFI in patients with AMI at 72 hours compared with the healthy control group, and the levels of these cells were reduced 6 months post-AMI. Regarding the suppressive function of CD4 CD25 regulatory cells, they were dysfunctional at 3 and 6 months post-AMI. The frequency of CD69 Treg cells was similar between patients with AMI at 72 hours postinfarction and the control groups. Moreover, the frequency of CD69 Treg cells at 3 and 6 months postischemic event did not vary over time. Treg cells play a role in regulating inflammation after an AMI, and its function may be compromised in this pathology. This work is the first report to evaluate CD69 Foxp3- Treg cells in AMI patients.
