abstract

• Given the price tag of commercially available devices, developing a low-cost, portable pupilometer based on the Raspberry Pi platform is significant for advancing clinical and research applications in neurology and circadian rhythm studies. This study aimed to design and characterize a pupilometer capable of assessing pupillary light response (PLR) to different wavelengths and its relationship with circadian cycles. Using a Raspberry Pi, a no-infrared filter (NoIR) camera, and custom software, the device was tested on a healthy 24-year-old female subject over 20 days, measuring responses to 635 nm (red) and 463 nm (blue) light stimuli at two daily intervals (8:00 AM and 8:00 PM) in both eyes. Results showed that blue light induced greater pupillary constriction than red light (F(1)= 284.37, p=6.9e-27), with more pronounced responses in the morning (F(1)=12.02, p=0.001), likely due to higher parasympathetic activity. Significant lateral asymmetry (F(1)=12.36, p=0.0008) was also observed in the pupillary response to blue light, suggesting potential intracranial factors. These findings demonstrate the pupilometer%27s efficacy in capturing detailed pupillary dynamics, proposing its utility to evaluate pupillary light response in connection with circadian rhythms and lateral asymmetry, providing an affordable solution.

authors

• Guevara Codina Edgar

publication date

• 2024-01-01

published in

• Revista Mexicana de Ingenieria Biomedica  Journal

keywords

• biomedical instrumentation; circadian rhythms; pupillometry

Digital Object Identifier (DOI)

• 10.17488/RMIB.45.3.4

PubMed ID

start page

• 68

end page

• 79

volume

• 45

issue

• 3