abstract

• Cannabis is widely recognized as a medicinal plant owing to bioactive cannabinoids. However, it is still considered a narcotic plant, making it hard to be accessed. Since the biosynthetic pathway of cannabinoids is disclosed, biotechnological methods can be employed to produce cannabinoids in heterologous systems. This would pave the way toward biosynthesizing any cannabinoid compound of interest, especially minor substances that are less produced by a plant but have a high medicinal value. In this context, microalgae have attracted increasing scientific interest given their unique potential for biopharmaceutical production. In the present review, the current knowledge on cannabinoid production in different hosts is summarized and the biotechnological potential of microalgae as an emerging platform for synthetic production is put in perspective. A critical survey of genetic requirements and various transformation approaches are also discussed. © 2022 Informa UK Limited, trading as Taylor %26 Francis Group.

authors

• Bolaños-Martínez O.C.
• Malla A.
• Rosales Mendoza Sergio
• Vimolmangkang S.

publication date

• 2022-01-01

funding provided via

• Chulalongkorn University, CU  Grant

published in

• Critical Reviews in Biotechnology  Journal

keywords

• Cannabinoids; chloroplast transformation; heterologous expression; microalgae; nuclear transformation; synthetic biology Genetic engineering; Microorganisms; Synthetic biology; Bioactives; Biosynthetic pathway; Cannabinoids; Chloroplast transformation; Heterologous expression; Heterologous systems; Medicinal plants; Micro-algae; Nuclear transformations; Synthetic biology; Microalgae

Digital Object Identifier (DOI)

• 10.1080/07388551.2022.2071672

PubMed ID

• 35762029

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