abstract

• Since their discovery, arylamine N-acetyltransferases 1 and 2 (NAT1 and NAT2, respectively) have been associated with the metabolism of xenobiotics. NAT2 is the main factor in the therapeutic success of tuberculosis treatment due to its role in the biotransformation of isoniazid. However, researchers have started to investigate the possible participation of NAT1 and NAT2 (NATs) in carcinogenesis, although the mechanisms have not been elucidated fully. NATs enzymatic activity is essential in some types of cancer, such as breast cancer and acute lymphoblastic leukemia. Whether NAT1 and/or NAT2 participate in insulin resistance level in diabetes mellitus or in the immune system remains to be explored. Therefore, it is clear that its role in cell physiology has more implications than just metabolizing compounds. © 2022 Elsevier B.V.

authors

• Hernández-González O.
• Martínez-Leija M.E.
• Portales Pérez Diana Patricia
• Zavala-Reyes D.

publication date

• 2022-01-01

published in

• Biochimica et Biophysica Acta - Molecular Cell Research  Journal

keywords

• Acute lymphoblastic leukemia; Arylamine N-acetyltransferases; Diabetes; Immune metabolism; Lymphocytes arylamine acetyltransferase; arylamine acetyltransferase 1; arylamine acetyltransferase 2; unclassified drug; acyltransferase; arylamine acetyltransferase; acute lymphoblastic leukemia; cell cycle; chronic disease; degenerative disease; human; immune system; insulin dependent diabetes mellitus; non insulin dependent diabetes mellitus; nonhuman; protein function; Review; tuberculosis; genetics; immune system; metabolism; Acetyltransferases; Arylamine N-Acetyltransferase; Immune System

Digital Object Identifier (DOI)

• 10.1016/j.bbamcr.2022.119297

PubMed ID

• 35588943

start page

end page

volume

• 1869

issue

• 9