Base excess measured at hospital admission is useful for predicting diabetic ketoacidosis severity and resolution time in adult patients
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Background and aims: This study aimed to identify the biochemical factors measured at hospital admission that could predict diabetes ketoacidosis (DKA) resolution time in adult patients. Materials and methods: This retrospective study included 79 patients >18 years of age. Multivariate analyses were performed to determine which variables might predict DKA resolution time. Biochemical parameters between the two DKA resolution time groups were compared. Results: Using multiple linear regression models, acidosis time was found to decrease by 29 h if the pH value increased by one unit, 0.64 h if the base excess (BE) value increased by 1 mmol, and 1.09 h if the bicarbonate (HCO3−) value increased by 1 mmol. The biochemical parameters that differed between the two groups were pH, HCO3−, and BE. Patients with delayed resolution of DKA had a blood pH of 7.1 (±0.18), HCO3− of 5.1 mmol (2.9-11.6 mmol), and BE of -21.5 mmol (-28.2 to -14.4 mmol) at hospital admission. Conclusions: Lower pH, HCO3−, and BE values at hospital admission may predict longer DKA resolution times in adult patients. In addition, BE may predict DKA severity. © 2022 Diabetes India
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Base excess; Biochemical parameters; Diabetic ketoacidosis; Resolution time bicarbonate; glucose; human insulin; insulin glargine; phosphorus; potassium; sodium chloride; adult; alkalosis; Article; biochemical analysis; blood pH; correlation analysis; diabetic ketoacidosis; disease severity; female; fluid therapy; glucose level; hospital admission; human; hyponatremia; major clinical study; male; multiple linear regression analysis; multivariate analysis; phosphate blood level; potassium blood level; prediction; remission; retrospective study; diabetes mellitus; diabetic ketoacidosis; hospital; hospitalization; Adult; Diabetes Mellitus; Diabetic Ketoacidosis; Hospitalization; Hospitals; Humans; Retrospective Studies
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