Evaluation of sialic acid concentrations and its association with the use of hormonal contraceptives [Evaluación de las concentraciones de ácido siálico y su asociación con el uso de anticonceptivos]
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Objective: To evaluate the relationship between the use of HC and the concentration of Sialic acid (CSA) detected in the saliva of 120 women from San Luís Potosí, Mexico. Methods: Three groups were evaluated: control group, HC intake shorter than 4 years, and HC intake longer than 4 years. A questionnaire was applied, anthropometric measures were taken, and collection of saliva samples was carried out. The samples were analyzed with Raman-SERS, for which silver nanoparticles were synthesized, and the measurement of SA was held. Results: The concentrations were divided into three SA groups: normal (≤ 4 mg/dL), risk (> 4-7 mg/dL), and altered (> 7 mg/dL). The maximum CSA was detected, which was 9.2 mg/dL. All the volunteers who used the intrauterine system (IUS) and most of the ones who used the pills and subdermal implant (SI) presented risk and altered concentrations. Conclusions: That there is an association between the HC and the CSA, presenting a higher concentration, those volunteers who used IUS, contraceptive pills, and SI. © 2022 Sociedad Mexicana de Oncología.
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Breast cancer; Hormonal contraceptive; Raman spectroscopy; SERS; Sialic acid hormonal contraceptive agent; sialic acid; silver nanoparticle; Article; body mass; breast cancer; cancer diagnosis; contraceptive behavior; controlled study; female; human; human experiment; maximum concentration; photon correlation spectroscopy; questionnaire; Raman spectrometry; risk factor; saliva; saliva level; zeta potential
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