abstract

• We have shown that a 15,000 kDa polymer of Ang II (Ang II-POL) at maximal concentration upon a sustained action on the AT1R of rat coronary endothelial luminal membrane (CELM) produced sustained vasoconstriction and inotropic effects, and a lack of CELM AT1R internalization. In contrast, an equivalent concentration of the monomer Ang II (1 kDa) caused transient effects: desensitization, associated with the expected progressive internalization of CELM AT1R. It is accepted that AT1R Internalization into the cell, results from the CELM agonist-receptor complex sequestration into vesicles which depends on the internalization proteins: β-arrestin, clathrin and dynamin.

authors

• Castillo Hernández Jesús Ramón
• Maldonado Cervantes Martha Imelda
• Rubio R.

publication date

• 2021-01-01

funding provided via

• CONACYT 101850  Grant

published in

• FASEB Journal  Journal

keywords

Digital Object Identifier (DOI)

• 10.1096/fasebj.2021.35.S1.05053

PubMed ID

start page

end page

volume

• 35

issue

• S1