selected publications

• article

  • Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).  Journal of Biological Chemistry.  287:40266-40278. 2012-01-01
  • Hypercholesterolemia induces up-regulation of K ACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.  Journal of Biological Chemistry.  287:4925-4935. 2012-01-01
  • PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4–S5 linker.  Proceedings of the National Academy of Sciences of the United States of America.  109:E2399-E2408. 2012-01-01
  • A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P2.  Nature Chemical Biology.  4:624-631. 2008-01-01