abstract

• This study aims to assess the impact of unilateral increases in carotid stiffness on cortical functional connectivity measures in the resting state. Using a novel animal model of induced arterial stiffness combined with optical intrinsic signals and laser speckle imaging, resting state functional networks derived from hemodynamic signals are investigated for their modulation by isolated changes in stiffness of the right common carotid artery. By means of seed-based analysis, results showed a decreasing trend of homologous correlation in the motor and cingulate cortices. Furthermore, a graph analysis indicated a randomization of the cortex functional networks, suggesting a loss of connectivity, more specifically in the motor cortex lateral to the treated carotid, which however did not translate in differentiated metabolic activity. © 2013 Optical Society of America.

authors

• Guevara Codina Edgar
• Lesage F.

publication date

• 2013-01-01

published in

• Biomedical Optics Express  Journal

keywords

• Optical constants; Optics; Arterial stiffness; Common carotid artery; Functional connectivity; Functional network; Hemodynamic signals; Laser speckle imaging; Metabolic activity; Resting-state functional connectivities; Stiffness; calcium chloride; deoxyhemoglobin; hydrobromic acid; animal experiment; animal model; arterial stiffness; article; brain blood flow; cingulate gyrus; common carotid artery; electrocardiogram; fluorescence imaging; functional neuroimaging; hemodynamic parameters; hyperbaric oxygen; image analysis; male; metabolic rate; motor cortex; mouse; nonhuman; oxygen consumption; resting state network; retrosplenial cortex; somatosensory cortex; tracheotomy; visual cortex; Animalia

Digital Object Identifier (DOI)

• 10.1364/BOE.4.002332

PubMed ID

start page

• 2332

end page

• 2346

volume

• 4

issue

• 11